Immunotoxins pp 483-491 | Cite as

Treatment of leukemia patients with T101 ricin A chain immunotoxins

  • G. Laurent
  • A. E. Frankel
  • A. A. Hertler
  • D. M. Schlossman
  • P. Casellas
  • F. K. Jansen
Part of the Cancer Treatment and Research book series (CTAR, volume 37)

Abstract

Cancer chemotherapies, despite recent advances, are still limited because of their toxic effects and lack of efficacy on the nonproliferating fraction of malignant cells. The use of agents which could target specifically malignant cells might improve the selectivity of systemic chemotherapy. As an illustration of the promise of this concept, some monoclonal antibodies (MoAb) directed against a tumor-associated antigen have been used in vivo to treat cancer patients, including non-B, non-T acute lymphoblastic leukemias (CALL) [1], T-ALL [2], B and T cell lymphomas [3–7], chronic lymphocytic leukemias (CLL) [8–10], or solid tumors [11–13].

Keywords

Toxicity Lymphoma Leukemia Doxorubicin Leucine 

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Copyright information

© Kluwer Academic Publishers 1988

Authors and Affiliations

  • G. Laurent
  • A. E. Frankel
  • A. A. Hertler
  • D. M. Schlossman
  • P. Casellas
  • F. K. Jansen

There are no affiliations available

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