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Immunotoxin enhancers

  • Chapter
Immunotoxins

Part of the book series: Cancer Treatment and Research ((CTAR,volume 37))

Abstract

Site-specific toxin delivery has been achieved by coupling monoclonal antibodies to the A chain subunit of phytotoxins such as ricin and abrin. Such hybrid molecules, termed A chain immunotoxins (A ITs), are now currently prepared according to standardized methods and their biological activities have been studied in detail.The major advantage of A ITs is their low nonspecific toxicity in vivo which allows a safe utilization in human patients (see Chapter 7 for review by Jansen et al. and Chapter 27 for review by Laurent et al.). However, although these conjugates showed stringent specific cytotoxicity, their efficiencies vary greatly from one IT to another. Also, A ITs generally proved to be less active than the original whole toxins towards target cells, suggesting that the role of the B chain not only consists of binding the toxin to the cell surface but also of increasing A chain activity, probably by promoting its transmembrane passage into the cytosol.

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Authors
  1. P. Casellas
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  2. F. K. Jansen
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Editors and Affiliations

  1. Department of Medicine Division of Hematology/Oncology, Duke University Medical Center, Box 3898 DUMC, Durham, North Carolina, 27710, USA

    Arthur E. Frankel

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© 1988 Kluwer Academic Publishers

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Casellas, P., Jansen, F.K. (1988). Immunotoxin enhancers. In: Frankel, A.E. (eds) Immunotoxins. Cancer Treatment and Research, vol 37. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1083-9_19

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  • DOI: https://doi.org/10.1007/978-1-4613-1083-9_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8419-2

  • Online ISBN: 978-1-4613-1083-9

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