Proteases II pp 485-491 | Cite as

Elastase-α1-Proteinase Inhibitor: An Early Indicator of Septicemia and Bacterial Meningitis in Childhood

  • Ch. P. Speer
  • M. Rethwilm
  • M. Gahr
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 240)

Abstract

Neonatal septicemia and meningitis are still a significant cause of morbidity and mortality1,2,3, in addition, systemic bacterial infections as well as bacterial meningitis in childhood are potentially lifethreatening diseases that require prompt recognition and early and appropriate therapy. Recently elastase-α1-proteinase inhibitor complex (E-α1-PI) has been introduced as a valuable indicator of systemic bacterial infections in neonates4.

Keywords

Pneumonia Diarrhea Neutropenia Meningitis Lasma 

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References

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    G. H. McCracken, Jr., Perinatal bacterial diseases, in: “Textbook of Pediatric Infectious Diseases”, R.D. Feigin, ed., W. B. Saunders, Philadelphia (1981).Google Scholar
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    G. S. Philip, “Neonatal sepsis and meningitis”, G.K. Hall, Boston (1985).Google Scholar
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    Ch. P. Speer, D. Hauptmann, P. Stubbe, and M. Gahr, Neonatal septicemia and meningitis in Göttingen, West-Germany, Pediatr. Infect. Pis. 4:36 (1985).CrossRefGoogle Scholar
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    Ch. P. Speer, A. Ninjo, and M. Gahr, Elastase-α1-proteinase inhibitor in early diagnosis of neonatal septicemia, J. Pediatr. 108:987 (1986).PubMedCrossRefGoogle Scholar
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    S. Neumann, G. Gunzer, N. Hennrich, and H. Lang, “PMN-Elastase Assay”: Enzyme immunoassay for human polymorphonuclear elastase complexed with α1-proteinase inhibitor, J. Clin. Chem. Clin. Biochem. 22:693 (1984).PubMedGoogle Scholar
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    F. K. Tegtmeyer and J. Otte, Early diagnosis of neonatal infections by leukocyte-elastase, Eur. J. Pediatr. 143:249 (1985).Google Scholar
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    Ch. P. Speer and M. Gahr, Leukozytenindizes, C-reaktives Protein und PMN-Elastase/α1-Proteinaseinhibitorkomplex in der Frühdiagnostik der neonatalen Sepsis, Monatsschr. Kinderheilkd. 133:595 (1985).Google Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Ch. P. Speer
    • 1
  • M. Rethwilm
    • 1
  • M. Gahr
    • 1
  1. 1.Dept. of PediatricsUniversity of GöttingenGöttingenGermany

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