Proteases II pp 485-491 | Cite as

Elastase-α1-Proteinase Inhibitor: An Early Indicator of Septicemia and Bacterial Meningitis in Childhood

  • Ch. P. Speer
  • M. Rethwilm
  • M. Gahr
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 240)


Neonatal septicemia and meningitis are still a significant cause of morbidity and mortality1,2,3, in addition, systemic bacterial infections as well as bacterial meningitis in childhood are potentially lifethreatening diseases that require prompt recognition and early and appropriate therapy. Recently elastase-α1-proteinase inhibitor complex (E-α1-PI) has been introduced as a valuable indicator of systemic bacterial infections in neonates4.


Bacterial Meningitis Tuberculin Skin Test Aseptic Meningitis Increase Plasma Level Acute Diarrhea 
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    S. Neumann, G. Gunzer, N. Hennrich, and H. Lang, “PMN-Elastase Assay”: Enzyme immunoassay for human polymorphonuclear elastase complexed with α1-proteinase inhibitor, J. Clin. Chem. Clin. Biochem. 22:693 (1984).PubMedGoogle Scholar
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    Ch. P. Speer and M. Gahr, Leukozytenindizes, C-reaktives Protein und PMN-Elastase/α1-Proteinaseinhibitorkomplex in der Frühdiagnostik der neonatalen Sepsis, Monatsschr. Kinderheilkd. 133:595 (1985).Google Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Ch. P. Speer
    • 1
  • M. Rethwilm
    • 1
  • M. Gahr
    • 1
  1. 1.Dept. of PediatricsUniversity of GöttingenGöttingenGermany

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