Nutrition and Protease Activity
The influence of nutritional intake and nutritional status on the activity of tissue proteases has been the subject of research for many years. In general, two different aspects of this subject have been investigated: 1) The effects of protein malnutrition, calorie malnutrition and proteincalorie malnutrition on protease activity and the contribution of proteases to wasting in starvation; and 2) The effect of specific nutrient deficiencies on specific proteases. This manuscript will briefly review these two areas of research.
KeywordsProtease Activity Protein Malnutrition Angiotensin Converting Enzyme Activity Increase Plasma Renin Activity Serum Angiotensin Converting Enzyme Activity
Unable to display preview. Download preview PDF.
- 1.N.H. Munro, and M.C. Crim, The proteins and amino acids, in: Modern Nutrition in Health and Disease, 7th Edition, M.E.Shils, V.R.Young (eds.), Lea & Febiger, Philadelphia, pp. 1 (1988).Google Scholar
- 2.L.J. Hoffer, Starvation, in: Modern Nutrition in Health and Disease, 7th Edition, M.E.Shils, V.R.Young, Lea & Febiger, Philadelphia, pp. 774 (1988).Google Scholar
- 5.D.J. Millward, and J.C. Waterlow, Effect of nutrition on protein turnover in skeletal muscle, Federation Proc. 37: 2283 (1978).Google Scholar
- 7.S. Rosochacki, and D.J. Millward, Cathepsin D and acid autolytic activity in skeletal muscle of protein deficient, severely protein-energy restricted and refed rats. Proc. Nutr. Soc. 38(3): 137A (1979).Google Scholar
- 9.K. Wildenthal, A.R. Poole, A.M Glauert, and J.T. Dingle, Dietary Control of cardiac lysosomal enzyme activities. Recent Adv. Studies Cardiac Struct. Metab. 8: 519 (1975).Google Scholar
- 11.A.M. Samarel, E.A. Ogunro, A.G. Ferguson, P. Allenby, and M. Lesch, Rabbit cardiac immunoreactive cathepsin D content during starvationinduced atrophy. Am. J. Physiol. 240: H222 (1981).Google Scholar
- 14.A.L. Goldberg, The regulation of protein turnover by endocrine and nutritional factors, in: Plasticity of Muscle, D. Pette (ed.), Walter de Gruyter & Co., Berlin, p. 469 (1980).Google Scholar
- 16.F. Gomez, R.R. Galvan, J. Cravioto, and S. Frenk, Studies on the undernourished child - Enzymatic activity of the duodenal contents in children affected with third degree malnutrition. Pediatrics 13: 548 (1954).Google Scholar
- 24.I.M. Weinstock, A.D. Goldrich, and A.T. Milhorat, Enzyme studies in muscular dystrophy. I. Muscle proteolytic activity and vitamin E-deficiency. Proc. Soc. Exptl. Biol. Med. 88: 257 (1955).Google Scholar
- 25.T.R. Koszalka, K.E. Mason, and G. Krol, Relation of vitamin E to proteolytic and autolytic activity of skeletal muscle. J. Nutr. 73: 78 (1961).Google Scholar
- 31.L.P. Dornfeld, M.H. Maxwell, A. Waks, and M. Tuck, Mechnanisms of hypertension in obesity, Kidney Int. 32 (Suppl.22): S254 (1987).Google Scholar