Abstract
Previous studies in histochemical toxicology have shown that plasma (surface) membrane ectoenzymes seem to be more easily affected by exogenous noxae such as drugs and/or their metabolites than other enzymes, e.g. those in lysosomes, Golgi apparatus or the endoplasmic reticulum of rat and mouse organs (for literature see Gossrau et al., 1987 a). This might be due also to the localization of the surface membrane enzymes at the border between the extra- and intracellular space which xenobiotics have to cross on their way into or through the respective cells.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bach, P.H., Bonner, F.W., Bridges, J.W., and Lock, E.A., 1982, ’Nephrotoxicity, Assessment and pathogenesis’, Wiley and Sons, Chichester, New York, Brisbane, Toronto, Singapore.
Beck, F., Huxham, U.M., and Al Alonsi, L., 1984, Transport in yolk sac epithelium. Verh. Anat. Ges. 78:99.
Bettger, W. J., and O’Dell, B.L., 1981, A critical physiological role of zinc in the structure and function of biomembranes, Life Sci. 28:1425.
Carbone, R., Baldridge, A.B., Magen, A.B., Andrew, C.L., Koszalka, T.R., and Brent, R.L., 1986, Glucocorticoid and progesterone receptors in the yolk sac placenta, Placenta 7:425.
Forth, W., Henschler, D., and Rummel, W., 1984, “Allgemeine Pharmakologie und Toxikologie”, Wissenschaftsverlag, Bibliographisches Institut, Mannheim, Wien, Zürich.
Geyer, G., 1973, “Ultrahistochemie”, Fischer, Jena.
Gossrau, R., 1981, Investigation of proteinases in the digestive tract using 4-methoxy-2-naphthylamine (MNA) substrates, J. Histochem. Cytochem. 29:464.
Gossrau, R., Graf, R., Günther, R., Merker, H.-J., Vormann, J., Nau, H., and Stahlmann, R., 1987 a, in press, Enzyme cytochemistry for the risk assessment of drug administration during pregnancy with special reference to proteases, Acta histochem. Suppl..
Gossrau, R., Merker, H.-J., Günther, T., Graf, R., and Vormann, J., 1987 b, Enzymatic and morphological response of the thymus to drugs in normal and zn-deficient pregnant rats and their fetuses, Histochemistry 86:321
Gossrau, R., Graf, R., Ruhnke, M., and Hanski, C., 1987 c, Proteases in the human full-term placenta, Histochemistry 86:405.
Graf, R., and Gossrau, R., 1986 a, Enzyme cytochemistry of the yolk sac diverticula in the mature murine rodent placenta, Placenta 7:491.
Graf, R., and Gossrau, R., 1986 b, Enzyme cytochemistry of pregnant and nonpregnant mouse organs after triamcinolone acetonide treatment. Histochem. J. 18:666.
Hammarström, S., 1983, Leukotrienes. Ann. Rev. Biochem. 52:355.
Heller, C., Coivine, H., de Nicola, A.F., 1981, Binding of 3h dexamethasone by rat placenta, Endocrinology 108:1697.
Heymann, E., and Mentlin, R., 1984, Beeinflußt Dipeptidylpeptidase IV Blutdruck und Gerinnung?, Klin. Wschr. 62:2.
Karzel, K., and Liedtke, R.K., 1985, “Einführung in die Arzneimitteltherapie”. 2. Auf1., UTB, Fischer, Stuttgart.
Kenny, A.J., 1977, Proteinases associated with cell membranes, in: ’Proteinases in mammalian cells and tissues’, A.J. Barrett, ed., North Holland, Amsterdam, Oxford, New York.
Lojda, Z., Gossrau, R., and Schiebler, T.H., 1979, Enzyme histochemistry, A laboratory manual, Springer, Berlin, Heidelberg, New York.
Marley, M., 1985, The detection of drugs by histochemical procedures, in: ’Analytical methods in human toxicology’, A.S. Curvy, ed., part 1, Verlag Chemie, Weinheim, Deerfield Beach, Florida, Basel.
McDonald, J.K., and Barrett, A.J., 1986, ’Mammalian proteases’, A glossary and bibliography, Vol. 2, Exopeptidases, Academic Press, London, Orlando, San Diego, New York, Montreal, Sydney, Tokyo, Toronto.
McDonald, J.K., and Schwabe, C., 1977, Intracellular exopeptidases, in: ’Proteinases in mammalian cells and tissues’, A.J. Barrett., ed., North Holland, Amsterdam, New York, Oxford.
Meister, A., and Anderson, M.E., 1983, Glutathione, Ann. Rev. Biochem. 52: 711.
Prasad, A.S., 1979, Clinical, biochemical and pharmacological role of zinc, Ann. Rev. Pharmacol. Toxicol. 20:393.
Schardein, J.L., 1976, Drugs as teratogens, CRC Press, Cleveland, Ohio.
Silbernagl, S., Pfaller, W., Henle, H., and Wendel, A., 1978, Topology and function of renal γ-glutamyl transpeptidase, in: ’Functions of glutathione in liver and kidney’, H. Sels and A. Wendel, eds., Springer, Berlin, Heidelberg, New York.
Vallee, B.L., and Galdes, A., 1984, The metallobiochemistry of zinc enzymes, Adv., Enzymol. 56:283.
Vormann, J., Hollriegel, V., Merker, H.-J., and Giinther, T., 1986, Effect of salicylate on zinc metabolism in fetal and maternal rats fed normal and zinc deficient diets, Biol. Trace Element Res. 9:55.
Vormann, J., and Giinther, T., 1986, Development of fetal mineral and trace element metabolism in rats with normal as well as magnesium and zincdeficient diets, Biol. Trace Element Res. 9:37.
Wachsmuth, E.D., 1981, The potential role of histochemistry in pharmacology and toxicology, in: Histochemistry: The widening horizons, P.J. Stoward and J.M Vollak, eds., Wiley and Sons, Chichester.
Waddell, W.J., 1971, The distribution of cortisone-C in pregnant mice, Teratology 4:355.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Plenum Press, New York
About this paper
Cite this paper
Graf, R., Gossrau, R. (1988). Plasma Membrane Proteases as Useful Tool in Histochemical Toxicology. In: Hörl, W.H., Heidland, A. (eds) Proteases II. Advances in Experimental Medicine and Biology, vol 240. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1057-0_5
Download citation
DOI: https://doi.org/10.1007/978-1-4613-1057-0_5
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8313-3
Online ISBN: 978-1-4613-1057-0
eBook Packages: Springer Book Archive