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Proteases II pp 399–404Cite as

Significant Role of Protease Inhibition by Aprotinin in Myocardial Protection from Prolonged Cardioplegia with Hypothermia

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 240))

Abstract

Biochemical and morphological damage in the ischemic myocardium result from increased activity of proteases, particularly lysosomal enzymes. The concentration of lysosomal enzymes increases in the both myocardium in response to ischemia and the systemic circulation in response to extracorporeal circulation. Cold cardioplegia minimizes the effects of ischemia during open heart surgery. It has been reported that aprotinin protects the myocardium from ischemia followed by reperfusion by suppressing the release of lysosomal enzymes2,3.

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Reference

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Authors and Affiliations

  1. Dept. of Thoracic Surgery, Tokyo Medical and Dental University, School of Medicine, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113, Japan

    Makoto Sunamori, Ryuichi Innami, Hitoshi Fujiwara, Motoki Yokoyama & Akio Suzuki

Authors
  1. Makoto Sunamori
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  2. Ryuichi Innami
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  3. Hitoshi Fujiwara
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  4. Motoki Yokoyama
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  5. Akio Suzuki
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Editor information

Editors and Affiliations

  1. University of Freiburg, Freiburg, Federal Republic of Germany

    Walter H. Hörl

  2. University of Würzburg, Würzburg, Federal Republic of Germany

    August Heidland

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© 1988 Plenum Press, New York

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Sunamori, M., Innami, R., Fujiwara, H., Yokoyama, M., Suzuki, A. (1988). Significant Role of Protease Inhibition by Aprotinin in Myocardial Protection from Prolonged Cardioplegia with Hypothermia. In: Hörl, W.H., Heidland, A. (eds) Proteases II. Advances in Experimental Medicine and Biology, vol 240. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1057-0_48

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  • DOI: https://doi.org/10.1007/978-1-4613-1057-0_48

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8313-3

  • Online ISBN: 978-1-4613-1057-0

  • eBook Packages: Springer Book Archive

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