Abstract
Numerous renal diseases are accompanied by glomerular proteinuria. This syndrom is characterized by increased glomerular protein filtration and increased urinary protein excretion. Under normal conditions the proximal tubule absorbs most of the filtered proteins. In glomerular proteinuria the proximal reabsorption of proteins is increased (1). The uptake into the proximal tubule cells occurs by endocytosis. The uptake process is characterized by a high capacity (as compared with normal filtered loads), and a low affinity. Absorbed proteins are transferred into the lysosomal system. Within the heterolysosomes the proteins are catabolized to amino acids as shown in Figure 1.
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© 1988 Plenum Press, New York
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Olbricht, C.J. (1988). Effect of Glomerular Proteinuria on the Activities of Lysosomal Proteases in Isolated Segments of Rat Proximal Tubule. In: Hörl, W.H., Heidland, A. (eds) Proteases II. Advances in Experimental Medicine and Biology, vol 240. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1057-0_33
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DOI: https://doi.org/10.1007/978-1-4613-1057-0_33
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8313-3
Online ISBN: 978-1-4613-1057-0
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