Characterization and Clinical Role of Glomecular and Tubular Proteases from Human Kidney
As shown by histochemical studies glomeruli as well as the tubule apparatus exhibit characteristic distribution patterns of proteases (Kugler 1982, 1985, Lojaa et al. 1979). However, these data were predominantly obtained through investigating tissue sections from mice, rats or rabbits. Up to the present only few studies were performed on material from normal human kidney (Kugler et al. 1985, Scherberich et al. 1984). In addition, little is known about the physiological role of renal proteases, although some of them might be involved in cleavage of peptides and proteins, and subsequent tubular reabsorption of break down products (Baumann 1981, Kinne 1985). Recent studies presented evidence that a glomerular aminopeptidase (aminopeptidase A) of human kidney acts as an angiotensinase (angiotensinase A) possibly involved in maintaining the intrarenal balance of renin-angiotensin system (Kugler et al. 1985, Scherberich et al. . 1986, Wolf et al. 1986, 1987). In the present paper we report on further histo/biochemical properties of proteases from human kidney and emphasize will be placed on their possible role under normal and pathologcal conditions (e.g. Wanner et al. 1986).
KeywordsProximal Tubule Human Kidney Brush Border Membrane Fetal Kidney Sucrose Density Gradient Centrifugation
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