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Proteases II pp 275-282 | Cite as

Characterization and Clinical Role of Glomecular and Tubular Proteases from Human Kidney

  • Jürgen E. Scherberich
  • Gunter Wolf
  • Claudia Stuckhardt
  • Peter Kugler
  • Wilhelm Schoeppe
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 240)

Abstract

As shown by histochemical studies glomeruli as well as the tubule apparatus exhibit characteristic distribution patterns of proteases (Kugler 1982, 1985, Lojaa et al. 1979). However, these data were predominantly obtained through investigating tissue sections from mice, rats or rabbits. Up to the present only few studies were performed on material from normal human kidney (Kugler et al. 1985, Scherberich et al. 1984). In addition, little is known about the physiological role of renal proteases, although some of them might be involved in cleavage of peptides and proteins, and subsequent tubular reabsorption of break down products (Baumann 1981, Kinne 1985). Recent studies presented evidence that a glomerular aminopeptidase (aminopeptidase A) of human kidney acts as an angiotensinase (angiotensinase A) possibly involved in maintaining the intrarenal balance of renin-angiotensin system (Kugler et al. 1985, Scherberich et al. . 1986, Wolf et al. 1986, 1987). In the present paper we report on further histo/biochemical properties of proteases from human kidney and emphasize will be placed on their possible role under normal and pathologcal conditions (e.g. Wanner et al. 1986).

Keywords

Proximal Tubule Human Kidney Brush Border Membrane Fetal Kidney Sucrose Density Gradient Centrifugation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Jürgen E. Scherberich
    • 1
  • Gunter Wolf
    • 1
  • Claudia Stuckhardt
    • 1
  • Peter Kugler
    • 2
  • Wilhelm Schoeppe
    • 1
  1. 1.Dept. NephrologyUniversity HospitalFrankfurt am MainGermany
  2. 2.Dept. AnatomyUniversity WurzbürgGermany

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