Abstract
Electronegative charges of the glomerular filtration barrier play probably an important role in its impermeability to anionic proteins 1–9. Sialic acid 10 (present in laminin) and glycosaminoglycans 11 seem to be the major molecules responsible for this propriety. Neutral proteinases synthetized either by mesangial cells or by monocytes and neutrophils, infiltrating glomeruli in some pathologic states, are able to degrade GBM glycoproteins in vitro 12–14.
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RENNKE HG, COTRAN RS, VENKATACHALAM MA, Role of molecular charge in glomerular permselectivity : Tracer studies with cationized ferritins, J Cell Biol 67 : 638 (1975).
RENNKE HG, VENKATACHALAM MA, Glomerular permeability : In vivo tracer studies with polyanionic and polycationic ferritins, Kidney Int 11 : 44 (1977).
RENNKE HG, VENKATACHALAM MA, Structural determinants of glomerular permselectivity, Fed Proc 36 :2619 (1977).
KANWAR YS, FARQUHAR MG, Anionic sites in the glomerular basement membrane : In vivo and in vitro localization in the laminae rarae by cationic probes, J Cell Biol 81 : 137 (1979).
MICHAEL AF, BLAU E, VERNIER RL, Glomerular polyanion alteration in amionucleoside nephrosis, Lab Invest 23 : 649 (1970).
BOHRER MP, BAYLIS C, ROBERTSON CR, BRENNER BM, Mechanisms of puromycin-induced defects in the transglomerular passage of water and macromolecules, J Clin Invest 60 : 152 (1977).
CHIN J, SMITH M, DRUMMOND KN, Proteinuria and glomerular sialprotein (GSP) in experimental renal disease, (abstract), Clin Res 21 : 681, (1973).
CHANG RLS, DEEN WM, ROBERTSON CR, BRENNER BM, Permselectivity of the glomerular capillary wall : III. Restricted transport of polyanions, Kidney Int 8 : 212 (1975).
BENNETT CM, GLASSOCK RJ, CHANG RLS, DEAN WM, ROBERTSON CR, BRENNER BM, Permselectivity of the glomerular capillary wall : Studies of experimental glomerulonephritis in the rat using dextran sulfate, J Clin Invest 57 : 1287 (1976).
KANWAR YS, FARQUHAR MG, Detachment of endothelium and epithelium from the glomerular basement membrane produced by perfusion with neuraminidase, Lab Invest 42 : 375 (1980).
KANWAR YS, LINKER A, FARQUHAR MG, Increased permeability of the glomerular basement membrane to ferritin after removal of glycosaminoglycans (heparan sulfate) by enzyme digestion, J Cell Biol 86 : 688 (1980).
LOVETT DH, STERZEL B, KASHGARIAN M, RYAN JL, Neutral proteinase activity produced in vitro by-cells of the glomerular mesangium, Kidney Int 23 : 342 (1983).
DAVIES M, BARRET AJ, TRAVIS J, SANDERS E, COLES GA, The degradation of human glomerular basement membrane with purified lysosomal proteinases : Evidence for the pathogenic role of the polymorphonuclear leucocytes in glomerulonephritis, Clin Sci Mol Med 54 : 233 (1978).
DAVIES M, COLES GA, HUGHES KT, Glomerular basement membrane injury by neutrophil and monocyte neutral proteinases, Renal Pysiol 3 : 106 (1980).
DUBOIS CH, FOIDART JB, HAUTIER MB, DECHENNE CA, LEMAIRE MJ, MAHIEU PR, Proliferative glomerulonephritis in rats : Evidence that mononuclear phagocytes infiltrating the glomeruli stimulate the proliferation of endothelial and mesangial cells, Eur J Clin Invest 11 : 91 (1981).
RYAN BG, KARNOVSKY MJ, An ultrastructural study of the mechanism of proteinuria in aminonucleoside nephrosis, Kidney Int 8 : 219 (1975)
DAVIN JC, DAVIES M, FOIDART JM, FOIDART JB, DECHENNE CA, MAHIEU PR, Urinary excretion of neutral proteinases in nephrotic rats with a glomerular disease, Kidney Int 31 : 32 (1987).
STARKEY PM, Proteinases in mammalian cells and tissues, edited by BARRET AJ North Holland, Amsterdam, p.57 (1977).
KINGSBURY FB, CLARCK CP, The rapid determination of albumin in urine, J Lab Clin Med 11 : 981 (1926).
BRIDGES CR, MYERS BD, BRENTER BM, DEEN WM, Glomerular charge alterations in human minimal change nephropathy, Kidney Int 22 : 677 (1982).
VERNIER RL, KLEIN DJ, SISSON PS, MAHAN JD, OEGEMA TR, BROWN DM, Heparan sulfate-rich anionic sites in the human glomerular basement membrane : decreased concentration in congenital nephrotic syndrome, N Engl J Med 309 : 1001 (1983).
SANDERS E, COLES GA, DAVIES M, Lysosomal enzymes in human urine : Evidence for polymorphonuclear leucocyte proteinase involvement in the pathogenesis of human glomerulonephritis, Clin Sc Mol Med 54 : 667 (1978).
HÖRL WH, WANNER C, THAISS F, SCHOLLMEYER P, Detection of a metalloproteinase in patients with acute and chronic renal failure, Am J Nephrol 6 : 6 (1986).
SCHREINER GF, COTRAN RS, PARDO V, UNANUE ER, A mononuclear cell component in experimental immunological glomerulonephritis, J Exp Med 147 : 369 (1978).
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© 1988 Plenum Press, New York
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Davin, JC., Davies, M., Foidart, JM., Foidart, J.B., Dechenne, C.A., Mahieu, P.R. (1988). Relation Between Urinary Proteinases and Proteinuria in Rats with a Glomerular Disease. In: Hörl, W.H., Heidland, A. (eds) Proteases II. Advances in Experimental Medicine and Biology, vol 240. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1057-0_31
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DOI: https://doi.org/10.1007/978-1-4613-1057-0_31
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