Abstract
Proteinases and the control of their activity by inhibitors are involved in many biological processes (1). A proteinase/proteinase inhibitor imbalance hypothesis has been proposed to account for several pathological situations such as rheumatoid arthritis (2,3) or pulmonary emphysema (4). The latter is a reduction of lung function due to a greaterproteolytic degradation of elastin either by an increase of proteinase release, deactivation of local proteinase inhibitors or a hereditary deficiency of α1-proteinase inhibitor (α1-PI). A disturbance of the elastin cross linking also appears to be involved (5,6). The elastase of human polymorphonuclear leukocytes (HLE) (7), which was shown to produce emphysema in several animal models possibly plays a prominent role (8). The appearance of a HLE-induced emphysema could be prevented by administering a corresponding proteinase inhibitor (9). Inhibitors of this elastase and their interaction with the enzyme, especially in the presence of the physiological substrate elastin, are thus of particular interest.
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© 1988 Plenum Press, New York
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Beckmann, J., Mehlich, A., Wenzel, H.R., Tschesche, H. (1988). Semisynthetic Inhibitors of Human Leukocyte Elastase and their Protective Effect on Lung Elastin Degradation in Vitro. In: Hörl, W.H., Heidland, A. (eds) Proteases II. Advances in Experimental Medicine and Biology, vol 240. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1057-0_13
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DOI: https://doi.org/10.1007/978-1-4613-1057-0_13
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