Skip to main content

Monoclonal Antibodies Recognizing Inter-Alpha-Trypsin-Inhibitor and its Related Fragments - Evidence for the Involvement of the Proteinase Inhibitor in Cutaneous (Patho-)Physiology

  • Conference paper
Proteases II

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 240))

Abstract

Proteolytic enzymes and their regulatory counterparts - the proteinase inhibitors - are likely to play an important role in the physiology and pathophysiology of human epidermis and dermis1. Numerous proteinases have been identified in the human skin 1,2,3 and have subsequently been characterized by chemical and immunological methods.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. V. K. Hopsu-Havu, J. E. Fräki, and N. Järvinen, Proteolytic enzymes in the skin, in: “Proteinases in mammalian cells and tissues,” Barrett, ed., Biomedical Press, Elsevier/North-Holland (1977).

    Google Scholar 

  2. C. Justus, S. Müller, and M. D. Kramer, A monoclonal antibody recognizing plasminogen/plasmin -Altered reactivity in psoriatic lesions, Br. J. Dermatol., (in press).

    Google Scholar 

  3. J. E. Fraki, G. S. Lazarus, and R. S. Gilgor, Correlation of epidermal plasminogen activator activity with disease activity in psoriasis, Br. J. Dermatol. 108:39 (1983)

    Article  PubMed  CAS  Google Scholar 

  4. W. Gebhard and K. Hochstrasser, Inter-alpha-trypsin inhibitor and its close relatives, in: “Proteinase Inhibitors,” Barrett and Salvesen, eds., Biomedical Division, Elsevier Science Publishers BV (1986)

    Google Scholar 

  5. K. Hochstrasser and E. Wachter, Kunitz-type proteinase inhibitors derived by limited proteolysis of the Inter-alpha-Trypsin Inhibitor, Hoppe Seyler’s Z. Physiolog. Chem., 364:1679 (1983).

    Article  CAS  Google Scholar 

  6. J. H. Peters, H. Baumgarten, and M. Schulze, Monoklonale Antikörper. Herstellung und Charakterisierung. Springer-Verlag, Berlin, Heidelberg, New York, Tokyo (1985).

    Google Scholar 

  7. G. Coruh and D. Y. Mason, Serum proteins in human squamous epithelium, Br. J. Dermatol. 102:497 (1980)

    Article  PubMed  CAS  Google Scholar 

  8. E. L. McKeehan, Y. Sakagami, H. Hiroyoshi, and K. McKeehan, Two apparent human endothelial cell growth factors from human hepatoma cells are tumor-associated proteinase inhibitors, J. Biol. Chem. 261:5378 (1986).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Plenum Press, New York

About this paper

Cite this paper

Justus, C., Hochstrasser, K., Kramer, M.D. (1988). Monoclonal Antibodies Recognizing Inter-Alpha-Trypsin-Inhibitor and its Related Fragments - Evidence for the Involvement of the Proteinase Inhibitor in Cutaneous (Patho-)Physiology. In: Hörl, W.H., Heidland, A. (eds) Proteases II. Advances in Experimental Medicine and Biology, vol 240. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1057-0_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-1057-0_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8313-3

  • Online ISBN: 978-1-4613-1057-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics