Abstract
Proteolytic enzymes and their regulatory counterparts - the proteinase inhibitors - are likely to play an important role in the physiology and pathophysiology of human epidermis and dermis1. Numerous proteinases have been identified in the human skin 1,2,3 and have subsequently been characterized by chemical and immunological methods.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
V. K. Hopsu-Havu, J. E. Fräki, and N. Järvinen, Proteolytic enzymes in the skin, in: “Proteinases in mammalian cells and tissues,” Barrett, ed., Biomedical Press, Elsevier/North-Holland (1977).
C. Justus, S. Müller, and M. D. Kramer, A monoclonal antibody recognizing plasminogen/plasmin -Altered reactivity in psoriatic lesions, Br. J. Dermatol., (in press).
J. E. Fraki, G. S. Lazarus, and R. S. Gilgor, Correlation of epidermal plasminogen activator activity with disease activity in psoriasis, Br. J. Dermatol. 108:39 (1983)
W. Gebhard and K. Hochstrasser, Inter-alpha-trypsin inhibitor and its close relatives, in: “Proteinase Inhibitors,” Barrett and Salvesen, eds., Biomedical Division, Elsevier Science Publishers BV (1986)
K. Hochstrasser and E. Wachter, Kunitz-type proteinase inhibitors derived by limited proteolysis of the Inter-alpha-Trypsin Inhibitor, Hoppe Seyler’s Z. Physiolog. Chem., 364:1679 (1983).
J. H. Peters, H. Baumgarten, and M. Schulze, Monoklonale Antikörper. Herstellung und Charakterisierung. Springer-Verlag, Berlin, Heidelberg, New York, Tokyo (1985).
G. Coruh and D. Y. Mason, Serum proteins in human squamous epithelium, Br. J. Dermatol. 102:497 (1980)
E. L. McKeehan, Y. Sakagami, H. Hiroyoshi, and K. McKeehan, Two apparent human endothelial cell growth factors from human hepatoma cells are tumor-associated proteinase inhibitors, J. Biol. Chem. 261:5378 (1986).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Plenum Press, New York
About this paper
Cite this paper
Justus, C., Hochstrasser, K., Kramer, M.D. (1988). Monoclonal Antibodies Recognizing Inter-Alpha-Trypsin-Inhibitor and its Related Fragments - Evidence for the Involvement of the Proteinase Inhibitor in Cutaneous (Patho-)Physiology. In: Hörl, W.H., Heidland, A. (eds) Proteases II. Advances in Experimental Medicine and Biology, vol 240. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1057-0_10
Download citation
DOI: https://doi.org/10.1007/978-1-4613-1057-0_10
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8313-3
Online ISBN: 978-1-4613-1057-0
eBook Packages: Springer Book Archive