Skip to main content
SpringerLink
Log in

Ontogeny of Adrenergic and Opioid Effects on Separation Vocalizations in Rats

  • Chapter
The Physiological Control of Mammalian Vocalization

Abstract

Altricial mammals are capable of forming a variety of associations and relationships which allow the infant to recognize home and caretaker (Brake, 1981; Johanson & Hall, 1979; Kehoe & Blass, 1986a, 1986b; Pedersen, Williams, & Blass, 1982; Rudy & Cheatle, 1979; Smith & Spear, 1978). These learned affectional relationships are of great significance to the infant’s survival and perhaps for adult motivated behaviors, as seen, for example, in males’ reproductive behavior depending on postnatal olfactory experience (Fillion & Blass, 1986). Recent studies have investigated the central mechanisms that might underlie the development of such important relationships and emotions (Kehoe & Blass, 1986b, 1986c, 1986d, 1986e; Panksepp, 1981; Panksepp, Siviy, & Normansell, 1985; Spear, Enters, Aswad, & Louzan, 1985). Exploration of the neurobiology mediating the ontogeny of affective behavior may lead to an understanding of infant responsivity, adult motivated behaviors and possibly anxiety disorders. Mammalian infant separation from parents and siblings evokes a quantifiable emotional response, namely, vocalizations. Neonatal rats under various social and thermal conditions emit ultrasonic cries in the range of 30–50 KHz which is well beyond the range of human hearing (Allin & Banks, 1972; Noirot, 1972).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Allin, J. T., and Banks, E. M., 1972, Functional aspects of ultrasound production by infant albino rats (Rattus norvegicus). Animal Behaviour, 20:175.

    Article  PubMed  CAS  Google Scholar 

  • Anden, N. E., Grabowska, M., and Strombom, U., 1976, Different alpha-adrenoreceptor in the central nervous system mediating biochemical and functional effects of Clonidine and receptor blocking agents. Naunyn Schmiedebergs Arch Pharmacologia, 292:43.

    Article  CAS  Google Scholar 

  • Barrett, B. A., Caza, P., Spear, N. E., and Spear, L., 1982, Wall climbing, odors from the home nest and catecholaminergic activity in rat pups. Physiology & Behavior, 29:501.

    Article  CAS  Google Scholar 

  • Bayon, A., Shoemaker, W. J., Bloom, F. E., Mauss, A., and Guillemin, R., 1979, Perinatal development of the endorphin-and enkephalin-containing systems in the rat brain. Brain Research, 179:93.

    Article  PubMed  CAS  Google Scholar 

  • Belluzzi, J. D., and Stein, L., 1977, Enkephalin may mediate euphoria and drive reduction reward. Nature, 266:556.

    Article  PubMed  CAS  Google Scholar 

  • Brake, S. C., 1981, Suckling infant rats learn a preference for a novel olfactory stimulus paired with milk delivery. Science, 211:506.

    Article  PubMed  CAS  Google Scholar 

  • Campbell, B. A., Lytle, L. D., and Fibiger, H. C., 1969, Ontogeny of adrenergic arousal and cholinergic inhibitory mechanisms in the rat. Science, 166:635.

    Article  PubMed  CAS  Google Scholar 

  • Campbell, B. A., and Mabry, P. D., 1977, The role of catecholamines in behavioral arousal during ontogenesis. Psychopharmacologia, 31:253.

    Article  Google Scholar 

  • Carlton, P. L., 1969, Brain acetylcholine and inhibition, in: “Reinforcement and Behavior,” J.T. Tapp, ed., Academic Press, New York.

    Google Scholar 

  • Clendeninn, N. J., Petraitis, M., and Simon, E. J., 1976, Ontological development of opiate receptors in rodent brain. Brain Research, 118: 157.

    Article  PubMed  CAS  Google Scholar 

  • Coyle, J. T., and Pert, C. B., 1976, Ontogenetic development of 3H-naloxone binding in rat brain. Neuropharmacology, 15:550.

    Article  Google Scholar 

  • Drew, G. M., Gower, A. J., and Marriott, A. S., 1979, Alpha2-adrenoceptors mediate clonidine-induced sedation in the rat. British Journal of Pharmacology, 67:133.

    PubMed  CAS  Google Scholar 

  • Fillion, T., and Blass, E. M., 1986, Infantile experience with suckling odors determines adult sexual behavior in male rats. Science, 231: 729.

    Article  PubMed  CAS  Google Scholar 

  • Goodlett, C. R., Valentino, M. L., Resnick, O., and Morgane, P. J., 1985, Altered development of responsiveness to Clonidine in severely malnourished rats. Pharmacology Biochemistry & Behavior, 23:567.

    Article  CAS  Google Scholar 

  • Harris, J. C., and Newman, J. D., 1985, Alpha-2 adrenergic receptor involvement in adult male squirrel monkey vocal behavior. Society for Neuroscience Abstracts, 11:5.

    Google Scholar 

  • Harris, J. C., and Newman, J. D., 1986, Synergistic effects of alpha2 adrenergic and opiate receptor blockade on vocalizations in adult squirrel monkeys. Society for Neuroscience Abstracts, 12:1133.

    Google Scholar 

  • Hartley, E. J., and Seeman, P., 1983, Development of receptors for dopamine and noradrenaline in rat brain. European Journal Pharmacology, 91:391.

    Article  CAS  Google Scholar 

  • Hennessy, M. B., Kaplan, J. N., Mendoza, S. P., Lowe, E. L., and Levine, S., 1979, Separation distress and attachment in surrogate-reared squirrel monkeys. Physiology and Behavior, 23:1017.

    Article  PubMed  CAS  Google Scholar 

  • Herman, B. H., and Panksepp, J., 1978, Effects of morphine and naloxone on separation distress and at attachment: Evidence for opiate mediation of social effect. Pharmacology Biochemistry Behavior, 9:213.

    Article  CAS  Google Scholar 

  • Hunter Jr., G. A., and Reid, L. D., 1983, Assaying addiction liability of opioids. Life Sciences, 33:393.

    Article  PubMed  CAS  Google Scholar 

  • Insel, T. R., Hill, J. L., and Mayor, R. B., 1986, Rat pup ultrasonic isolation calls: Possible mediation by the benzodiazepine receptor complex. Pharmacology Biochemistry & Behavior, 24:1263.

    Article  CAS  Google Scholar 

  • Johanson, I. B., and Hall, W. G., 1979, Appetitive learning in 1-day-old rat pups. Science, 205:419.

    Article  PubMed  CAS  Google Scholar 

  • Kehoe, P., and Blass, E. M., 1986a, Conditioned aversions and their memories in 5-day-old rats during suckling. Journal of Experimental Psychology: Animal Behavior Processes, 12:40.

    Article  PubMed  CAS  Google Scholar 

  • Kehoe, P., and Blass, E. M., 1986b, Behaviorally functional opioid systems in infant rats: I. Evidence for olfactory and gustatory classical conditioning. Behavioral Neuroscience, 100:359.

    Article  PubMed  CAS  Google Scholar 

  • Kehoe, P., and Blass, E. M., 1986c, Behaviorally functional opioid system in infant rats: II. Evidence for pharmacological, physiological and psychological mediation of pain and stress. Behavioral Neuroscience, 100:624.

    Article  PubMed  CAS  Google Scholar 

  • Kehoe, P., and Blass, E. M., 1986d, Central nervous system mediation of positive and negative reinforcement in neonatal albino rats. Developmental Brain Research, 27:69.

    Article  Google Scholar 

  • Kehoe, P., and Blass, E.M., 1986e, Opioid-mediation of separation distress in 10-day-old rats: Reversal of stress with maternal stimuli. Developmental Psychobiology, 19:385.

    Article  PubMed  CAS  Google Scholar 

  • Kehoe, P., and Harris, J. C., 1986, Separation vocalizations: Ontogeny of adrenergic effects in rat pups. Society for Neuroscience Abstracts, 12:1144.

    Google Scholar 

  • Kellogg, C., and Lundborg, P., 1972, Ontogenetic variations in responses to L-DOPA and monoamine receptor-stimulating agents. Psychopharmacologia, 23:187.

    Article  PubMed  CAS  Google Scholar 

  • Kellogg, C., and Wennerstrom, G., 1974, An ontogenic study on the effect of catecholamine receptor-stimulating agents on the turnover of noradrenaline and dopamine in the brain. Brain Research, 79:451.

    Article  PubMed  CAS  Google Scholar 

  • Khachaturian, H., Alessi, N. E., Munfakh, N., and Watson, S. J., 1983, Ontogeny of opioid and related peptides in the rat CNS and pituitary: An immunocytochemical study. Life Sciences, 33:61.

    Article  PubMed  CAS  Google Scholar 

  • Kobayashi, K., and Eiduson, S., 1970, Norepinephrine and dopamine in the developing chick brain. Developmental Psychobiology, 3:13.

    Article  PubMed  CAS  Google Scholar 

  • Lanier, L. P., Dunn, A. J., and Van Hartesveldt, C., 1976, Development of neurotransmitters and their function in brain, in; “Reviews of Neuroscience, Vol. II,” S. Ehrenpresis & I. J. Copin, eds., Raven Press, New York.

    Google Scholar 

  • Morris, M. J., Dausse, J. P., Devynck, M. A., and Meyer, P., 1980, Ontogeny of alphal and alpha2-adrenoceptors in rat brain. Brain Research, 190:268.

    Article  PubMed  CAS  Google Scholar 

  • Noirot, E., 1972, Ultrasounds and maternal behavior in small rodents. Developmental Psychobiology, 5:371.

    Article  PubMed  CAS  Google Scholar 

  • Nomura, Y., Oki, K., Segawa, T., 1980, Pharmacological characterization of central alpha-adrenoceptors which mediate clonidine-induced locomotor hypoactivity in the developing rat. Naunyn Schmiedebergs Arch Pharmacologia, 311:41.

    Article  CAS  Google Scholar 

  • Nomura, Y., and Segawa, T., 1979, The effects of alpha-adrenoceptor antagonists and metamide on clonidine-induced locomotor stimulation in the infant rat. British Journal of Pharmacology, 66:531.

    PubMed  CAS  Google Scholar 

  • Panksepp, J., 1981, Brain opioids — a neurochemical substrate for narcotic and social dependence, in: “Theory in Psychopharmacology, 1,” S.J. Cooper. ed., Academic Press, London.

    Google Scholar 

  • Panksepp, J., Meeker, R., and Bean, D. H., 1980, The neurochemical control of crying. Pharmacology Biology and Behavior, 12:437.

    Article  CAS  Google Scholar 

  • Panksepp, J., Siviy, S., and Normansell, L. A., 1985, Brain opioids and social emotions, in: “Biology of social attachments,” M. Reite & T. Fields, eds., Academic Press, New York.

    Google Scholar 

  • Panksepp, J., Vilberg, T., Bean, N. J., Coy, D. H., and Kastin, A. J., 1978, Reduction of distress vocalization in chicks by opiate-like peptides. Brain Research Bulletin, 3:663.

    Article  PubMed  CAS  Google Scholar 

  • Pedersen, P. E., Williams, C. L., and Blass, E. M., 1982, Activation and odor conditioning of suckling behavior in 3-day-old albino rats. Journal of Experimental Psychology: Animal Behavior Processes, 8: 329.

    Article  PubMed  CAS  Google Scholar 

  • Raiteri, M., Maura, G., and Versace, P., 1983, Functional evidence for two stereochemically different alpha2 adrenoceptors regulating central norepinephrine and serotonin release. Journal of Pharmacology and Experimental Therapy, 224:679.

    CAS  Google Scholar 

  • Reinstein, D. K., and Isaacson, R. L., 1977, Clonidine sensitivity in the developing rat. Brain Research, 135:378.

    Article  PubMed  CAS  Google Scholar 

  • Reinstein, D. K., McClearn, D., and Isaacson, R. L., 1978, The development of responsivity to dopaminergic agents. Brain Research, 150:216.

    Article  PubMed  CAS  Google Scholar 

  • Rudy, J. W., and Cheatle, M. D., 1979, Ontogeny of association learning: Acquisition of odor aversions by neonatal rats, in: “Ontogeny of learning and memory,” N. E. Spear and B. A. Campbell, eds., Erlbaum, Hillsdale, NJ.

    Google Scholar 

  • Smith, G. J., and Spear, N. E., 1978, Effects of the home environment on withholding behaviors and conditioning in infant and neonatal rats. Science, 202:327.

    Article  PubMed  CAS  Google Scholar 

  • Smotherman, W. P., Bell, R. W., Starzec, J., Elias, J., and Zachman, T. A., 1974, Maternal responses to infant vocalizations and olfactory cues in rats and mice. Behavioral Biology, 12:55.

    Article  PubMed  CAS  Google Scholar 

  • Spear, L. P., and Brick, J., 1979, Cocaine-induced behavior in the developing rat. Behavioral and Neural Biology, 26:401.

    Article  PubMed  CAS  Google Scholar 

  • Spear, L. P., Enters, E. K., Aswad, M. A., and Louzan, M., 1985, Drug and environmentally-induced manipulations of the opiate and serotonergic alter nociception in neonatal rat pups. Behavioral and Neural Biology, 44:1.

    Article  PubMed  CAS  Google Scholar 

  • Stein, L., 1978, Reward transmitters: Catecholamines and opioid peptides, in: “Psychopharmacology: A Generation of Progress,” M. A. Lipton, A. DiMascio and K. F. Killam, eds., Raven, New York.

    Google Scholar 

  • Zebrowska-Lupina, I., Przegalinski, M., Sloniec, M., Kleinrok, Z., 1977, Clonidine-induced locomotor hyperactivity in rats. The role of central postsynaptic alpha-adrenoceptors. Naunyn-Schmiedeberg’s Arch Pharmacologia, 297:227.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Trinity College, Hartford, CT, USA

    Priscilla Kehoe

Authors
  1. Priscilla Kehoe
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. National Institutes of Health, Poolesville, Maryland, USA

    John D. Newman

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Plenum Press, New York

About this chapter

Cite this chapter

Kehoe, P. (1988). Ontogeny of Adrenergic and Opioid Effects on Separation Vocalizations in Rats. In: Newman, J.D. (eds) The Physiological Control of Mammalian Vocalization. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1051-8_16

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-1051-8_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8310-2

  • Online ISBN: 978-1-4613-1051-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation