Abstract
By a popular tradition, a baby delivered when still wrapped in the amniotic sac is destined for great luck throughout his or her life: people say that he or she was born with a caul. Besides its putative magic properties, a true scientific interest in the “protective” activity of the amniotic membrane dates back to the first half of the Century, when a certain number of experiments were carried out, in Germany and Eastern Europe, to investigate its possible clinical applications. Satisfactory results were achieved by using sheets of sterile, dried human amnion as a peritoneal graft in gangrene or as a biological dressing for the treatment of extensive wounds and burns, always recording a definite improvement of wound healing and decrease of pain1.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
J.D. Trefold, M. Trefold-Sauder, The amnion in surgery, past and present, Am. J. Obstet. Gynecol. 134:833 (1979).
M. Adinolfi, C.A. Akle, I. McColl et al., Expression of HLA antigens, β2-microglobulin and enzymes by human amniotic epithelial cells, Nature 295:325 (1982).
B. Scaggiante, A. Pineschi, M. Sustersich et al., Successful therapy of Niemann-Pick disease by implantation of human amniotic membrane, Transpl. 44:59 (1987).
J.B. Lloyd and P.A. Griffiths, Enzyme replacement therapy of lysosomal disease, in:“Lysosomes in biology and pathology”, J.T. Dingle, R.T. Dean, W. Sly,eds., Elsevier Science Publ., New York, 6:517 (1984).
A. Tylki-Szymanska, D. Macjeko, M. Kidawa and U. Jablonska-BudajAmniotic tissue transplantation as a trial of treatment in some lysosomal storage diseases, J.Inher.Metab.Pis. 8:101 (1985).
A.M. Yeager, H.S. Singer, J.R. Berck et al., A therapeutic trial of amniotic epithelial membranes in patients with lysosomal storage diseases, Am. J. Med. Genet. 22:347 (1985).
C. Akle, I. McColl, M. Dean, et al., Transplantation of amniotic epithelial membranes in patients with mucopolysaccharidoses, Exp. clin. Immunogenet. 2:43 (1985).
J. Muenzer, E.F. Neufeld, G. Constantopoulos, et al., Amniotic membrane implantation in mucoplysaccharidosis, Ped. Res. 19:25lA (1985).
A. Hasilik, K. von Figura, E. Conzelmann, et al., Lysosomal enzyme precursors in human fibroblasts, Eur. J. Biochem. 125:317 (1982).
E.F. Neufeld, T.W. Lein, L.J. Shapiro, Inherited disorders of lysosomal metabolism, Annu. Rev. Biochem. 44:357 (1975). 11.I. Olsen, H. Muir, R. Smith et al., Direct enzyme transfer from lymphocytes is specific, Nature 306:705 (1983).
H. Burgos, Angiogenic and growth factors in human amnio-chorion and placenta, Eur. J. Clin. Invest. 13:289 (1983).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Plenum Press, New York
About this paper
Cite this paper
Scaggiante, B., Pineschi, A., Bembi, B., Agosti, E., Romeo, D. (1988). Repeated Implantations of Human Amniotic Epithelial Cells as a Curative Therapy of Niemann-Pick Disease. In: Salvayre, R., Douste-Blazy, L., Gatt, S. (eds) Lipid Storage Disorders. NATO ASI Series, vol 150. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1029-7_98
Download citation
DOI: https://doi.org/10.1007/978-1-4613-1029-7_98
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8300-3
Online ISBN: 978-1-4613-1029-7
eBook Packages: Springer Book Archive