Skip to main content

Comparison of Human Membrane-Bound β-Glucosidases: Lysosomal Glucosylceramide-β-Glucosidase and Non-Specific β-Glucosidase

  • Conference paper
Lipid Storage Disorders

Part of the book series: NATO ASI Series ((NSSA,volume 150))

  • 111 Accesses

Abstract

In human tissues, the multiple molecular forms of β-glucosidases can be classified in three different groups (1-4).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. S.P. Peters, P. Coyle and R.H. Glew, Differenciation of β-glucocerebrosidase from β-glucosidase in human tissues using sodium taurocholate, Arch. Biochem. Biophys., 175:569 (1976)

    Article  PubMed  CAS  Google Scholar 

  2. M. Yaqoob and M. Carroll, Isoenzymes of membrane-bound β-glucosidase of human spleen, Biochem. J., 185:541 (1980).

    PubMed  CAS  Google Scholar 

  3. A. Maret, R. Salvayre, A. Negre, L. Douste-Blazy, Separation par electrofocalisation des formes moleculaires de la β-glucosidase splenique de sujet normal et de maladie de Gaucher, Biomedicine. 33:82 (1980).

    PubMed  CAS  Google Scholar 

  4. A. Maret, R. Salvayre, A. Negre and L. Douste-Blazy, Proprietes des formes moleculaires de la β-glucosidase et de la β-glucocerebrosidase de rate humaine normale et de maladie de Gaucher, Eur. J. Biochem., 115:455 (1981).

    Article  PubMed  CAS  Google Scholar 

  5. S.P. Peters, R.H. Glew, R.E. Lee, in “Practical Enzymology of Sphingolipidoses” Glew R.H., Peters S.P. eds) A.R. Liss, New-York, 71–100 (1977).

    Google Scholar 

  6. T. Dinur, K.M. Osiecki, D.T. Fabbro, G. Legier, S. Gatt, R.J. Desnick, G.A. Grabowski, Human acid β-glucosidase: Isolation and amino-acid sequence of a peptide containing the catalytic site, Proc. Natl. Acad. Sci., 83:1660 (1986).

    Article  PubMed  CAS  Google Scholar 

  7. G.A. Grabowski, S. Gatt, J. Kruse, R.J. Desnick, Human lysosomal β-glucosidase: kinetic characterisation of the catalytic, aglycon and hydrophobic binding site, Arch. Biochem. Biophvs., 231:144 (1984).

    Article  CAS  Google Scholar 

  8. J. Sorge, C. West, B. Westwood, E. Beutler, Molecular cloning and nucleotide sequences of the human glucocerebrosidase gene, Proc. Natl. Acad. Sci., 82:7289 (1985).

    Article  PubMed  CAS  Google Scholar 

  9. E. Beutler, J.A. Sorge, C. West, T. Gelbart, B. Westwood, A. Zimran, W. Kuhl, The molecular biology of Gaucher disease, in “Lipid Storage Disorders: Biological and Medical aspects”, R. Salvayre, L. Douste-Blazy and S. Gatt, eds, NATO-ASI Series (this volume), Plenum, New-York, 19–28 (1988)

    Google Scholar 

  10. N. Dance, R.G. Price, D. Robinson and J.L. Stirling, β-galactosidase, β-glucosidase and N-acetyl-β-glucosaminidase in human kidney, Clin. Chim. Acta. 24:189 (1969).

    Article  PubMed  CAS  Google Scholar 

  11. R.H. Glew, S.P. Peters and A.R. Christopher, Isolation and characterization of β-glucosidases from the cytosol of rat kidney cortex, Biochim. Biophys. Acta. 422:179 (1976).

    Google Scholar 

  12. Y. Ben Yoseph, M.B. Fiddler, R. Rousson, H.L. Nadler, Multiple carbohydratecleaving specificities in human acidic and neutral glucosidases, Biochim. Biophys. Acta. 568: 386 (1979).

    PubMed  CAS  Google Scholar 

  13. M.A. Chester, B. Hultberg, P.A. Ockerman, The common identity of five glycosidases in human liver, Biochim. Biophys. Acta. 429:517 (1976).

    PubMed  CAS  Google Scholar 

  14. A. Maret, R. Salvayre, A. Negre and L. Douste-Blazy, Substrate specificity of the human splenic non-specific soluble β-glucosidase, Eur. J. Biochem., 133:283 (1983).

    Article  PubMed  CAS  Google Scholar 

  15. R. Salvayre, A. Negre, A. Maret, G. Lenoir, L. Douste-Blazy, Separation and properties of molecular forms of alpha-galactosidase and alpha-N-acetylgalactosaminidase from blood lymphocytes and lymphoid cell lines transformed by Epstein-Barr virus, Biochim. Biophys. Acta. 659:445 (1981).

    PubMed  CAS  Google Scholar 

  16. A. Maret, R. Salvayre, M. Samadi, L. Douste-Blazy, β-Glucosidase isoenzymes in Epstein-Barr virus-transformed lymphoid cell lines from normal subjects and patients with type 1 Gaucher disease, Enzyme. 37:206 (1987).

    Google Scholar 

  17. T. Dinur, G.A. rabowski, R.J. Desnick, S. Gatt, Synthesis of fluorescent derivative of glucosylceramide for the sensitive determination of glucocerebrosidase activity, Anal. Biochem. 136:223 (1984).

    Article  PubMed  CAS  Google Scholar 

  18. A. Maret, R. Salvayre, A. Negre, G. Lenoir, M. Vuillaume and L. Douste-Blazy, Glucosylceramidase deficiency in EBV-transformed lymphoid cell lines from Gaucher patients, IRCS Med. Sci., 11:214 (1983).

    CAS  Google Scholar 

  19. G. Beauregard, A. Maret, R. Salvayre, M. Potier, The radiation inactivation method as a tool to study structure-function relationship in proteins, in: “Methods of Biochemical Analysis”, D. Glick, ed., J.Wiley, 32:313–343 (1987).

    Google Scholar 

  20. A. Maret, M. Potier, R. Salvayre, L. Douste-Blazy, Modification of subunit interaction in membrane-bound acid β-glucosidase from Gaucher disease, FEBS Lett.. 160:93 (1983).

    Article  PubMed  CAS  Google Scholar 

  21. A. Maret, M. Potier, R. Salvayre, L. Douste-Blazy, Modifications of the molecular weight of membrane-bound non-specific β-glucosidase in type 1 Gaucher disease determined in situ by the radiation inactivation method, Biochim. Biophvs. Acta. 799:91 (1984).

    Article  CAS  Google Scholar 

  22. F. Choy, M. Woo, M. Potier, In situ radiation inactivation size of fibroblast membrane-bound acid β-glucosidase in Gaucher type 1, type 2 and type 3 disease, Biochim. Biophvs. Acta. 870:76 (1986).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Plenum Press, New York

About this paper

Cite this paper

Maret, A., Salvayre, R., Potier, M., Legler, G., Beauregard, G., Douste-Blazy, L. (1988). Comparison of Human Membrane-Bound β-Glucosidases: Lysosomal Glucosylceramide-β-Glucosidase and Non-Specific β-Glucosidase. In: Salvayre, R., Douste-Blazy, L., Gatt, S. (eds) Lipid Storage Disorders. NATO ASI Series, vol 150. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1029-7_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-1029-7_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8300-3

  • Online ISBN: 978-1-4613-1029-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics