Molecular Cloning of Olfactory-Specific Gene Products

  • Frank L. Margolis


The specificity of cell, tissue, and organismal development and differentiation derives from selective regulation of differential gene expression along spatial and temporal coordinates. Understanding the mechanisms controlling these events is among the key problems in contemporary biology. These questions are being addressed by many laboratories applying a wide range of techniques to a variety of organisms and neural systems. Our concern here is to consider those approaches that may help identify the genes that are specifically expressed and selectively regulated in the various cells of the olfactory system. Furthermore, it is our intention to identify the products of these various genes and to determine how they may be related to the diverse functional activities of the olfactory system. Thus, the major thrust of this chapter is to consider the use of biochemical and molecular biological approaches in the study of the regulation of specific gene expression in the peripheral olfactory system.


Olfactory Bulb Nasal Mucosa Olfactory Receptor Olfactory Epithelium Olfactory System 
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© Plenum Press, New York 1988

Authors and Affiliations

  • Frank L. Margolis
    • 1
  1. 1.Department of Neuroscience, Roche Institute of Molecular BiologyRoche Research CenterNutleyUSA

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