Cloning of the Duchenne/Becker Muscular Dystrophy Locus

  • Anthony P. Monaco
  • Louis M. Kunkel
Part of the Advances in Human Genetics book series (AHUG, volume 17)


The identification and molecular cloning of the Duchenne muscular dystrophy (DMD) gene represents the first step in the long path toward a basic understanding and potential therapy of this human genetic disorder. One of the most interesting challenges to modern medicine is to understand and alter the course of the many genetic disorders. There are more than 3000 known genetic disease phenotypes, yet the vast majority are poorly understood at the level of the underlying biochemical disturbance. The techniques of molecular biology have changed the way these disorders are analyzed, and presumably the next decade will see an explosion of new understanding in the various ways that genotype affects phenotype. Duchenne muscular dystrophy thus serves as an example of the prospects to come, and this review can serve as a guide toward similar work with other genetic disorders.


Muscular Dystrophy Duchenne Muscular Dystrophy Duchenne Muscular Dystrophy Duchenne Muscular Dystrophy Patient Restriction Fragment Length Polymorphism 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Anthony P. Monaco
    • 1
    • 2
  • Louis M. Kunkel
    • 1
    • 2
  1. 1.Division of Genetics and Mental Retardation Center Children’s Hospital Department of PediatricsHarvard Medical SchoolBostonUSA
  2. 2.Program in Neuroscience Harvard UniversityCambridgeUSA

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