Abstract
The release of neurotransmitter from nerve terminals is triggered by the influx of calcium ions through voltage-activated channels1–3. In excitable tissues there appear to be a number of different types of Ca channels, based on physiological parameters (single channel conductance, ion selectivity, voltage-dependent activation and inactivation properties) and sensitivity to pharmacological agents (especially dihydropyridines, w-conotoxin (wCgTx) and Cd ions). The type of Ca channel underlying synaptic transmission has not been established, although recent studies of mammalian neurons suggest that N-type channels are involved4, 22.
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Umbach, J.A., Gundersen, C.B. (1988). Expression of Presynaptic Calcium Channels in Xenopus Oocytes. In: Grinnell, A.D., Armstrong, D., Jackson, M.B. (eds) Calcium and Ion Channel Modulation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0975-8_7
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DOI: https://doi.org/10.1007/978-1-4613-0975-8_7
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