Abstract
Cells respond to a variety of extracellular stimuli by utilizing intracellular messenger systems. In recent years several intracellular messengers have been identified as mediators of changes in the electrical activity of excitable cells. The best understood messengers in nerve cells are Ca2+ and cyclic AMP. An increase of free Ca2+is a common by-product of action potentials, while a variety of neurotransmitters and hormones increase internal cyclic AMP. The study of what these messengers do, and their mechanisms of action, has extended our understanding of neuronal function. Now cellular neurophysiology is confronted with a new challenge: to understand how intracellular messenger systems interact within a neuron. Interactions between intracellular messenger systems may have a special importance in neurons, allowing for the biochemical integration of intrinsic electrical activity such as action potentials with synaptic and hormonal influences. It is likely that studying interactions between intracellular messenger systems will elucidate basic mechanisms involved in generating long-term changes in neuronal function.
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© 1988 Plenum Press, New York
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Kramer, R.H., Levitan, E.S., Levitan, I.B. (1988). Physiological Interaction Between Calcium and Cyclic AMP in an Aplysia Bursting Pacemaker Neuron. In: Grinnell, A.D., Armstrong, D., Jackson, M.B. (eds) Calcium and Ion Channel Modulation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0975-8_19
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DOI: https://doi.org/10.1007/978-1-4613-0975-8_19
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