Abstract
According to a general scheme that has emerged from extensive studies carried out during recent decades, membrane ion channels and cell metabolism represent operationally independent systems involved in the maintenance of cellular reactivity. Metabolism creates the necessary prerequisites for the generation of ionic currents forming transmembrane electrochemical gradients by active ion transport. Ion channels use these gradients but not metabolism as a source of energy for producing transmembrane electric currents. This scheme seemed to be universal for a long time; however now more and more experimental data have become available indicating that in certain cases the function of ion channels may be directly influenced by intracellular metabolic processes. The present paper presents a survey of such data obtained in our laboratory and discusses their significance for the understanding of cell functioning.
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© 1988 Plenum Press, New York
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Kostyuk, P.G. (1988). Cytoplasmic Modulation of Ion Channel Functioning in the Neuronal Membrane. In: Grinnell, A.D., Armstrong, D., Jackson, M.B. (eds) Calcium and Ion Channel Modulation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0975-8_15
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DOI: https://doi.org/10.1007/978-1-4613-0975-8_15
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