Abstract
The induction of hepatocellular tumors depends upon the nature of the chemical agent (1), its requirement for activation to ultimate carcinogenic moiety (2), enzymatic competence of tissue(s) to activate the procarcinogen (3–5), the interaction of ultimate carcinogenic moiety with specific macromolecular site(s) (6,7), the rate of removal of the formed adduct(s) (8), the degree of macromolecular repair (9,10), caloric intake (11–13), immune competence, and hormonal environment of the host (14–17), The interplay of all these factors contribute in varying degrees to the neoplastic expression in the liver. The species, strain (18), age at treatment (19), and sex (19) of the animals may influence the degree of the agent’s activation. In addition, the age at treatment may affect the macromolecular damage-repair ratio and consequently the degree of fixation of the residual macromolecular lesion(s) (20).
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Vesselinovitch, S.D., Mihailovich, N., Negri, S. (1988). Sex Hormones as Modulators of Liver Tumor Development. In: Roberfroid, M.B., Préat, V. (eds) Experimental Hepatocarcinogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0957-4_5
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DOI: https://doi.org/10.1007/978-1-4613-0957-4_5
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