Abstract
Initiation is a necessary event without which nothing happens and beyond which everything is possible. Indeed, after a sufficient initiating treatment, the carcinogenic process can either evolve naturally or operationally be modulated. The factors that modulate an initiated carcinogenesis can have positive or negative effects. When the incidence and/ or the yield of cancer is increased and/or the latency period is decreased by the modulating treatment, the modulation is considered as positive whereas a treatment which decreases the incidence and/or the yield of cancer and/or increases the latency period is considered as a negative modulator. (Roberfroid, 1987)
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bannasch, P. (1968), , The cytoplasm of Hepatocytes during Carcinogenesis, Rec. Results Cancer Res., 19, 1–105.
Bannasch, P., (1986), Preneoplastic Lesions as End Points in Carcinogenecity Testing I. Hepatic Neoplasia, Carcinogenesis, 7, 689–695
Barbason,H., Smoliar,V., Fridman-Manduzio,A. and Betz, E. (1979), Effect of Discontinuation of Chronic Feeding of Diethylnitrosamine on the Development of Hepatomas in Adult rats, Br.J. Cancer, 40,260–267
Barbason,H., Rassenfosse,C. and Betz, E., (1983), Promotion Mechanism of Phenobarbital and Partial Hepatectomy in DENA Hepatocarcinogenesis and Cell Kinetics Effect, Br.J.Cancer, 47, 517–525
Bartsch,H., Préat,V., Aitio,A., Cabral J.and Roberfroid,M., (1987), Partial Hepatectomy of Rats Ten Weeks before Carcinogen Administration Enhances Liver Carcinogenesis Carcinogenesis, in press
Cayama,E., Tsuda,H., Sarma,D.S.R. and Farber, E. (1978), Initiation of Chemical Carcinogenesis Requires Cell Proliferation, Nature, 273, 60–62
Delzenne, N., personnal communication
de Gerlache,J., Taper., H.S., Lans,M., Préat,V. and Roberfroid,M., (1987), Dietary Modulation of Rat Liver Carcinogenesis, Carcinogenesis, 8, 337–340
Goshal, A. and Farber, E. (1984), The Induction of Liver Cancer by Dietary Deficiency of Choline and Methionine without Added Carcinogens, Carcinogenesis, 5, 1367–1370
Farber, E., Parker S. and Gruenstein M., (1976), The Resistance of Putative Premalignant Liver Cell Populations, Hyperplastic Nodules to the Acute Cytotoxic Effects of Some Hepatocarcinogens, Cancer Res., 3879–3887
Hicks, M., (1983), Pathological and Biochemical Aspects of Tumour Promotion, Carcinogenesis, 4, 1209–1214
Iversen,O. and Iversen U. (1982) Must Initiators Come First? Tumorigenic and Carcinogenci effects on Skin of 3-Methylcholanthrene and TPA in Various Sequences., Br.J. Cancer, 45, 912–920
Lans,M., de Gerlache,J., Préat,V., Taper,H.S. and Roberfroid M., (1983), Phenobarbital as a Promoter in the initiation/selection Process of Experiemntal Rat Hepatocarcinogenesis. Carcinogenesis, 4, 141–144
Pector,J.Cl, Presonnal communication
Peraino, C., Fry,R. and Staffeld,E. (1971), Reduction and Enhancement by Phenobarbital of Hepatocarcinogenesis Induced in Rats by 2-acetylaminofluorene. Cancer Res, 31, 1506–1512
Préat,V., Pector J.CL., Taper,H.S., Lans,M., de Gerlache,J. and Roberfroid,M. (1984), Promoting Effect of Portocaval Anastomosis in Hepatocarcinogenesis, Carcinogenesis 5, 1151–1154
Préat,V., de Gerlache,J., Lans,M., Taper,H.S. and Roberfroid M., (1986a), Comparative Analysis of the Promoting Effect of Phenobarbital, DDT, Nafenopin and Butylated hydroxytoluene in Rat Hepatocarcinogenesis, Carcinogenesis, 7, 1025–1029
Préat,V., Lans,M., de Gerlache,J., Taper,H. and Roberfroid M. (1986b), Comparison of the Biological Effect of Phenobarbital and Nafenopin on Rat Hepatocarcinogenesis, Jp..J.Cancer Res., 77, 629–638
Préat,V., de Gerlache,J., Lans,M. and Roberfroid,M., (1987a) Promoting Effect of Oxazepam in Rat Hepatocarcinogenesis, Carcinogenesis, 8, 97–100
Préat, V. and Roberfroid M., (1987b) Modulation of rat hepa tocarcinogenesis by Peroxisome Proliferators, 2nd International Conference on Anticarcinogenesis and Radiation Protection
Rao,P.M., Wagamine K., Ho,K., Roomi,W., Lairier,C., Rajalakshmi S. and Sarma, D.S.R. (1983), Dietary Orotic Acid Enhances the incidence of Gamma-glutamyl-transferase Positive Foci in Rat Liver Induced by Chemical Carcinogens, Carcinogenesis, 4, 1541–1545
Roberfroid,M. (1987), From Normal Cell to Cancer: an Overview introducing the Concept of Modulation of Carcinogenesis, in A. Maskens (ed). Concepts and Theories in Carcinogenesis, Excepta Medica Congress Series, Elsevier-Scientific Publishers, 157–167
Shivapurkar,N., Hoover,K.L. and Poirier, L. (1986), Effect of Methionine and Choline on Liver Tumor Promotion by Phenobarbital and DDT in Diethylnitrosamine-initiated Rats, Carcinogenesis, 7, 547–550
Sells, Katyal, S., Sell,S., Shinozuka, H., Lombardi,B.(1979) Induction of Foci of Altered Gamma-Glutamyl-Transpeptidase Positive Hepatocytes in Carcinogen Treated Rats Fed a Choline Deficient Diet, Br.J.Cancer, 40, 274–283
Solt,D. and Farber,E., (1976), New Principle for the Analysis of Chemical Carcinogenesis, Nature, 263, 701–703
Solt,D., Cayam,E., Tsuda,H., Enomoto,K, Lee,G. and Farber,E. (1983), Promotion of Liver Cancer Development by Brief Exposure to Dietary 2-acetylaminofluorene plus Partial Hepatectomy or Carbon Tetrachlride, Cancer Res.,43, 188 –191
Taper,H.S. (1978), The effect of Oestradiol-17-phenylpropionate and Oestradiol benzoate on N-nitrosomorpholine Induced liver Carcinogenesis in Ovariectomised female rats. Cancer, 42, 462–467
Teebor,G. and Becker,F., (1971), Regression and Persistance of Hyperplastic Nodules Induced by N-2-fluorenylaceta-mide and their Relationship to Hepatocarcinogenesis, Cancer Res., 31, 1–3
Van Rensselaer Potter (1984), Use of Two Sequetial Applications of Initiators in the Production of Hepatomas in the Rat, Cancer Res., 44, 2733–2736
Yager,J., Campbell,H., Longnecker,D., Roebuck; B. and M. Benoit, Enhancement of Hepatocarcinogenesis in Female Rats by Ethinyl Estrodiol and Mestranol but not Estradiol, Cancer Res., 44, 3862–3869
Williams G. (1982), Phenotypic Properties of Preneoplastic Rat Liver Lesions and Applications to Detection of Carcinogens and Tumor Promoters, Toxicol. Pathol.,10, 3–10
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Plenum Press, New York
About this paper
Cite this paper
Préat, V., Delzenne, N. (1988). Modulating Factors of Hepatocarcinogenesis. In: Roberfroid, M.B., Préat, V. (eds) Experimental Hepatocarcinogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0957-4_4
Download citation
DOI: https://doi.org/10.1007/978-1-4613-0957-4_4
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8264-8
Online ISBN: 978-1-4613-0957-4
eBook Packages: Springer Book Archive