Role of Oncogenes in Hepatocarcinogenesis

  • C. Guguen-Guillouzo
  • G. Baffet
  • P. L. Etienne
  • D. Glaise
  • N. Defer
  • M. Corral
  • D. Corcos
  • J. Kruh


Oncogenes are a set of genes which have been implicated in carcinogenesis. They are activated forms of proto-oncogenes which are part of the genetic complement of all normal cells. These genes are highly conserved during evolution suggesting that they play a critical role in some fundamental phenomena in life.


Liver Regeneration Oncogene Expression Cellular Oncogene Simian Sarcoma Virus Spontaneous Neoplastic Transformation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    M. CORRAL, L. TICHONICKY, C. GUGUEN-GUILLOUZO, D. CORCOS, M. RAYMONDJEAN, B. PARIS, J. KRUH and N. DEFER, Expression of c-fos oncogene during hepatocarcinogenesis, liver regeneration and in synchronized HTC cells, Exp. Cell Res. 160:427 (1985).PubMedCrossRefGoogle Scholar
  2. 2.
    M. CORRAL, B. PARIS, C. GUGUEN-GUILLOUZO, D. CORCOS, J. KRUH and N. DEFER, Increased expression of N-myc gene during normal and neoplastic rat liver growth, Exp. Cell Res. (1987) in press.Google Scholar
  3. 3.
    D. CORCOS, N. DEFER, M. RAYMONDJEAN, B. PARIS, M. CORRAL, L. TICHONICKY, J. KRUH, D. GLAISE, A. SAUNIER and C. GUGUEN-GUILLOUZO, Correlated increase of the expression of the c-ras genes in chemically induced hepatocarcinomas, Biochem. Biophys. Res. Commun., 122:259 (1984).PubMedCrossRefGoogle Scholar
  4. 4.
    E. SCHERER and P. EMMELOT. Foci of altered liver cells induced by a single dose of diethylnitrosamine and partial hepatectomy: their contribution to hepatocarcinogenesis in rat. Eur. J. Cancer, 11:145 (1975).PubMedGoogle Scholar
  5. 5.
    P. YASWEN, M. GOYETTE, P.R. SHANK and N. FAUSTO, Expression of c-Ki-ras, c-Ha-ras and c-myc in specific cell types during hepatocarcinogenesis, Mol Cell. Biol., 5:780 (1985).PubMedGoogle Scholar
  6. 6.
    S. HORIKAWA, K; SAKATA, M. HETANAKA and K. TSUDADA, Expression of c-myc oncogene in rat liver by a dietary manipulation. Biochem. Biophys. Res. Commun., 140:574 (1986).PubMedCrossRefGoogle Scholar
  7. 7.
    R. MAKINO, K. HAYASHI, S. SATO and T. SUGIMURA, Expression of the c-Ha-ras and c-myc genes in rat liver tumors. Biochem. Biophys. Res. Commun., 119:1096 (1984).CrossRefGoogle Scholar
  8. 8.
    F. TASHIRO, S. MORIMURA, K. HAYASHI, R. MAKINO, M. KAWAMURA, N. HORIKOSHI, K. NEMOTO, K. OHTSUBO, T. SUGIMURA and Y. UENO, Expression of the c-Ha-ras and c-myc genes in aflatoxin B1 induced hepatocellular carcinomas. Biochem. Biophys. Res. Commun., 138:858 (1986).PubMedCrossRefGoogle Scholar
  9. 9.
    T.A. DRAGANI, G. MANENTI, G. DELLA PORTA, S. GATTONI-CELLI and I.B. WEINSTEIN, Expression of retroviral sequences and oncogenes in murine hepatocellular tumors, Cancer Res., 46:1915 (1986).PubMedGoogle Scholar
  10. 10.
    F. ISHIKAWA, F. TAKAKU, M. OCHIAI, K. HAYASHI, S. HIROHASHI, M. TERADA, S. TAKAYAMA, M. NAGAO and T. SUGIMURA, Activated c-raf gene in a rt hepatocellular carcinoma induced by 2-amino-3-methylinidazo-[4,5,8] quinoline. Biochem. Biophys. Res. Commun., 132:186 (1985).PubMedCrossRefGoogle Scholar
  11. 11.
    P. YASWEN, N.T. HAYNER and N. FAUSTO. Isolation of oval cells by centrifugal elutriation and comparison with other cell types purified from normal and preneoplastic livers Cancer Res., 44:324 (1984).PubMedGoogle Scholar
  12. 12.
    X.K. ZHANG, D.P. HUANG, D.K. CHIU and J.F. CHIU, The expression of oncogenes in human developing liver and hepatomas, Biochem. Biophys. Res. Commun., 142:932 (1987).PubMedCrossRefGoogle Scholar
  13. 13.
    E. MOREL-CHANY, C. GUGUEN-GUILLOUZO, C. TRINCAL and M.F. SZAJNERT, Spontaneous neoplastic transformation in vitro of epithelial cells strains of rat liver: cytology, growth and enzymatic activities, Eur. J. Cancer, 14:1341 (1978).PubMedGoogle Scholar
  14. 14.
    G. BAFFET, M. RISSEL and GUGUEN-GUILLOUZO C. Synthesis and phosphorylation of cytoskeleton components during spontaneous neoplastic transformaiton of epithelial cells. Submitted.Google Scholar
  15. 15.
    T. R. FOX and P.G. WATANABE, Detection of a cellular oncogene in spontaneous liver tumors of B6C3F1 mice, Science, 228:596 (1985).PubMedCrossRefGoogle Scholar
  16. 16.
    R. MULLER, D.J. SLAMON, J.M. TREMBLAY, M.J. CLINE and I.M. VERMA, Differential expression of cellular oncogenes during pre- and postnatal development of the mouse, Nature, 299:640 (1982).PubMedCrossRefGoogle Scholar
  17. 17.
    T. IWANAGA, T. FUJITA, T. TSUCHIHASHI, K. YAMAGUSHI, K. ABE and N. YANAIHARA, Immunocytochemical detection of the c-myc oncogene product in human fetuses, Biochem. Res., 7:161 (1986).Google Scholar
  18. 18.
    K.A. ZIMMERMAN, G.D. YANCOPOULOS, R.G. COLLUM, R.K. SMITH N.E., KOHL, K.A. DENIS, M.M. NAU, O.N. WITTE, D. TORAN-ALLERANOL, C.E. GEE, J.D. MINNA and F.W. ALT, Differential expression of myc family genes during murine development, Nature 319:780 (1986).PubMedCrossRefGoogle Scholar
  19. 19.
    T. TANAKA, N. IDA, H. SHIMODA, C. WAKI, D.J.. SLAMON and M.J. CLINE, Organ specific expression of ras oncoproteins during growth and development of the rat, Mol. Cell. Biochem., 70:97 (1986).PubMedCrossRefGoogle Scholar
  20. 20.
    N. FAUSTO and P.R. SHANK, Oncogene expression in liver regeneration and hepatocarcinogenesis, Hepatology, 3:1016 (1983).PubMedCrossRefGoogle Scholar
  21. 21.
    N.L. THOMPSON, J.E. MEAD, L. BRAUN, M. GOYETTE, P.R. SHANK and N. FAUSTO, Sequential protooncogene expression during rat liver regeneration, Cancer Res., 46:3111 (1986).PubMedGoogle Scholar
  22. 22.
    R. MAKINO, K. HAYASHI and T. SUGIMURA, C-myc transcripts induced in rat liver at very early stage of regeneration or by cychloeximide treatment. Nature, 310:697 (1984).PubMedCrossRefGoogle Scholar
  23. 23.
    J.C. SAEZ, M.V.L. BENNETT and D.C SPRAY, Carbon tetrachloride at hepatotoxic levels blocks reversibly gap junctions between rat hepatocytes, Science, 236: 967 (1987).PubMedCrossRefGoogle Scholar
  24. 24.
    T. ENOMOTO and H. YAMASAKI, Lack of intercellular communication between chemically transformed and surrounding non transformed BALB/c 3T3 cells, Cancer Res., 44: 5200 (1984).PubMedGoogle Scholar
  25. 25.
    R.A. WEINBERG, The action of oncogenes in the cytoplasm and nucleus, Science, 230:770 (1985).PubMedCrossRefGoogle Scholar
  26. 26.
    D.A. SPANDIDOS, Mechanisms of carcinogenesis: the role of oncogenes, transcriptional enhancers and growth factors, Anticancer Res., 5:485 (1985).PubMedGoogle Scholar
  27. 27.
    R.F. DOOLITLE, M.W. HUNKAPILLER, L. HOOD et al. Simian sarcoma virus one gene v-sis is derived from the gene (or genes) encoding a platelet-derived growth factor, Science, 221:275 (1983).CrossRefGoogle Scholar
  28. 28.
    J. DOWNWARD, Y. YARDEN, E. MAYES, G. SCRACE, N. TOTTY, P. STOCKWELL, A. ULLRICH, J. SCHLESSINGER and M.D. WATERFIELD, Close similarity of epidermal growht factor receptor and v-erb-B oncogene protein sequences. Nature, 307:521 (1984).PubMedCrossRefGoogle Scholar
  29. 29.
    C WEINBERGER, C.C THOMPSON, E.S. ONG, R. LEBO, D.J. GRUOL and R.M. EVANS. The c-erb-A gene encodes a thyroid hormone receptor, Nature, 324:641 (1986).PubMedCrossRefGoogle Scholar
  30. 30.
    A. DEJEAN, L. BOUGUELERET, K.H. GRZESCHIK and P. TIOLLAIS, Hepatitis B virus DNA integration in a sequence homologousto v-erb-A and steroid receptor genes in a hepatocellular carcinoma, Nature, 322:70 (1986).PubMedCrossRefGoogle Scholar
  31. 31.
    M. CORRAL, N. DEFER, B. PARIS, M. RAYMONDJEAN, D. CORCOS, L. TICHONICKY, J. KRUH, D. GLAISE, B. KNEIP and C. GUGUEN-GUILLOUZO, Isolation and characteriziton of complementary DNA clones for genes oververexpression in chemically induced rat hepatomas, Cancer Res., 46:5119 (1986).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • C. Guguen-Guillouzo
    • 1
  • G. Baffet
    • 1
  • P. L. Etienne
    • 1
  • D. Glaise
    • 1
  • N. Defer
    • 2
  • M. Corral
    • 2
  • D. Corcos
    • 2
  • J. Kruh
    • 2
  1. 1.INSERM - U 49Hôpital PontchaillouRennes CédexFrance
  2. 2.Institut de Pathologie Moléculaire - 24ParisFrance

Personalised recommendations