Abstract
The mechanisms of hepatocarcinogenesis induced by nitrosamines have been mainly considered in relation to “initiation” processes. Alkylation of 06-guanine associated with DNA synthesis has been frequently correlated with point mutations to explain the emergence of putative preneoplastic foci and this has been directly connected with various types of tumorigenesis 1–4.
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© 1988 Plenum Press, New York
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Barbason, H., Bouzahzah, B., Massart, S., Brumioul, D., Robaye, B., Herens, C. (1988). Long Term Effect of Diethylnitrosamine (DEN) on the Production of Micronuclei in Precancerous Rat Liver. In: Roberfroid, M.B., Préat, V. (eds) Experimental Hepatocarcinogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0957-4_17
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DOI: https://doi.org/10.1007/978-1-4613-0957-4_17
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