Cholesterol Metabolism During Cell Proliferation

  • P. Pani
  • S. Dessì
  • B. Batetta
Conference paper


Cholesterol metabolism has been extensively studied for its role in cell replication and growth (1). Besides the fact that cholesterol is a constitutive physiological compound of plasma membranes, it is believed that intermediate molecules of its metabolism are directly implied with DNA synthesis (2). Several experimental reports support these assumptions. The following general considerations can be recalled:
  1. 1.

    A “continuous” flow of cholesterol synthesis is needed during cell proliferation in order to supply the cholesterol required for biogenesis of new membranes that must accompany cell growth (3).

  2. 2.

    The pioneering work of Siperstein showed the loss of feedback inhibition by cholesterol on hydroxy-methyl-glutaryl coenzyme A (HMGCoA) reductase in tumoral tissue (4).

  3. 3.

    In the last decade different Authors have repeatedly given “in vitro” experimental evidence that isoprenoid units are directly correlated with DNA synthesis (5–7).

  4. 4.

    Cholesterol synthesis and correlated metabolic pathways (hexose monophosphate (HMP) shunt, cholesterol esterification, lipoprotein metabolism) are synchronized with DNA synthesis and with the extent of parenchymal cell proliferation (8–12).



Cholesterol Esterification Cholesterol Synthesis Cholesterol Metabolism Lead Nitrate Acinar Cell Carcinoma 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • P. Pani
    • 1
  • S. Dessì
    • 1
  • B. Batetta
    • 1
  1. 1.Istituto di Farmacologia e Patologia BiochimicaUniversità di CagliariCagliariItaly

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