Cholesterol Metabolism During Cell Proliferation
A “continuous” flow of cholesterol synthesis is needed during cell proliferation in order to supply the cholesterol required for biogenesis of new membranes that must accompany cell growth (3).
The pioneering work of Siperstein showed the loss of feedback inhibition by cholesterol on hydroxy-methyl-glutaryl coenzyme A (HMGCoA) reductase in tumoral tissue (4).
In the last decade different Authors have repeatedly given “in vitro” experimental evidence that isoprenoid units are directly correlated with DNA synthesis (5–7).
Cholesterol synthesis and correlated metabolic pathways (hexose monophosphate (HMP) shunt, cholesterol esterification, lipoprotein metabolism) are synchronized with DNA synthesis and with the extent of parenchymal cell proliferation (8–12).
KeywordsCholesterol Esterification Cholesterol Synthesis Cholesterol Metabolism Lead Nitrate Acinar Cell Carcinoma
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