Cell Proliferation and Hepatocarcinogenesis

  • Hartmut M. Rabes


Carcinogenesis is intrinsically coupled with cell proliferation. Proliferation in excess characterizes a manifest malignant tumor, proliferation plays an important role during the latency period until the neoplastic phenotype emerges, and proliferation is essential during the initiation of transformation. This is apparently true for the development of all kinds of malignant tumors, induced by physical, chemical or viral factors, and applies also to hepatocarcinogenesis. This contribution is aimed at dissecting some critical phases of the carcinogenic process in the liver with respect to cell proliferation.


Partial Hepatectomy Phosphoglycerate Kinase Normal Hepatocyte Cell Cycle Time Liver Carcinogenesis 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Hartmut M. Rabes
    • 1
  1. 1.Institute of PathologyUniversity of MunichMunichGermany

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