Mobile, phagocytoeing cells were first observed in starfish larvae in 1882 by Elie Metchnikoff, who was subsequently able to demonstrate their central role in host defense against infection ln animals. In recognition of the significance of his discoveries, Metchnikoff was awarded the Nobel Prize in Physiology or Medicine in 1908. Since that time our understanding of the physiology and biochemistry of leukocytic cells has increased enormously; however, the microbicidal toxins produced by leukocytes and their disinfection mechanisms have remained poorly characterized, and are correspondingly the subject of increasing attention of medical researchers and biochemists.


NADPH Oxidase Human Neutrophil Polymorphonuclear Leukocyte Respiratory Burst Chronic Granulomatous Disease 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • James K. Hurst
    • 1
  1. 1.Department of Chemical and Biological SciencesOregon Graduate CenterBeavertonUSA

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