Skip to main content

Pathogenic Roles of TSH-Receptor Antibodies in Graves’ Disease

  • Chapter
Thyroid Autoimmunity
  • 17 Accesses

Abstract

Since the discovery of long acting thyroid stimulator, the significance of circulating abnormal thyroid stimulators or TSH-receptor antibodies in untreated patients with Graves’ disease has been investigated extensively by numerous investigators. However, the pathogenic roles of TSH-receptor antibodies for thyrotoxicosis of Graves’ disease are still not completely elucidated.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. N. Kuzuya, S.C. Chiu, H. Ikeda, H. Ikeda, H. Uchimura, K. Ito, and S. Nagataki, Correlation between Thyroid Stimulators and 3, 5, 3’- Triiodothyronine Suppressibility in Patients during Treatment for Hyperthyroidism with Thionamide Drugs: Comparison of Assays by Thyroid-Stimulating and Thyrotropin-Displacing Activities, J Clin Endocrinol Metab. 48: 706 (1979).

    Article  PubMed  CAS  Google Scholar 

  2. N. Yokoyama, M. Izumi, and S. Nagataki, Heterogeneity of Graves 1 IgG: Comparison of TSH Receptor Antibodies in Serum and in Culture Supernatants of Lymphocytes Transformed by EB Virus Infection, J Clin Endocrinol Metab. (in press).

    Google Scholar 

  3. S. Nagataki, Pathogenic Factors of Graves 1 disease, in: “Current problems in Thyroid reseach,” N. Ui, K. Torizuka, S. Nagataki, and K. Miyai, ed., Excerpta Medica, Amsterdam-Oxford-Princeton (1982).

    Google Scholar 

  4. N. Hamada, T. Okabe, K. Kubota, S.C. Chiu, H. Uchimura, T. Mimura, K. Ito, and S. Nagataki, Chronic Effect of TSH on Human Thyroid Tissue in Organ Culture, Proc Soc Exp Biol Med. 172: 153 (1983).

    PubMed  CAS  Google Scholar 

  5. S. Yamashita, M. Izumi, and S. Nagataki, Specific stimulatory effects of Graves’ IgG on the release of triiodothyronine from the patients’ own thyroids, Acta Endocrinol. 112: 204 (1986).

    PubMed  CAS  Google Scholar 

  6. M. Londei, G.F. Bottazzo, and M. Feldman, Human T-Cell Clones from Autoimmune Thyroid Glands: Specific Recognition of Autologous Thyroid Cells, Science. 228: 85 (1985).

    Article  PubMed  CAS  Google Scholar 

  7. T. Hanafusa, L. Chiovato, D. Doniach, R. Pujol-Borrell, R.C.G. Russell, G.F. Bottazzo, Aberrant expression of HLA-DR antigen on thyrocytes in Graves’ disease: relevance for autoimmunity, Lancet. 2: 1111 (1983).

    Article  PubMed  CAS  Google Scholar 

  8. M. Matsunaga, K. Eguchi, T. Fukuda, A. Kurata, H. Tezuka, C. Shimomura, T. Otsubo, N. Ishikawa, K. Ito, and S. Nagataki, Class II Major Histocompatibility Complex Antigen Expression and Cellular Interaction in Thyroid Glands of Graves’ Disease, J Clin Endocrinol Metab. 62: 723 (1986).

    Article  PubMed  CAS  Google Scholar 

  9. H. Tamai. H. Uno, Y. Hirota, S. Matsubayashi, K. Kuma, H. Matsumoto, L.F. Kumagai, T. Sasazuki, and S. Nagataki, Immunogenetics of Hashimoto’s and Graves’ Diseases, J Clin Endocrinol Metab. 60: 62 (1985).

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Plenum Press, New York

About this chapter

Cite this chapter

Nagataki, S. (1987). Pathogenic Roles of TSH-Receptor Antibodies in Graves’ Disease. In: Pinchera, A., Ingbar, S.H., McKenzie, J.M., Fenzi, G.F. (eds) Thyroid Autoimmunity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0945-1_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-0945-1_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8258-7

  • Online ISBN: 978-1-4613-0945-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics