Abstract
Since the discovery of long acting thyroid stimulator, the significance of circulating abnormal thyroid stimulators or TSH-receptor antibodies in untreated patients with Graves’ disease has been investigated extensively by numerous investigators. However, the pathogenic roles of TSH-receptor antibodies for thyrotoxicosis of Graves’ disease are still not completely elucidated.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
N. Kuzuya, S.C. Chiu, H. Ikeda, H. Ikeda, H. Uchimura, K. Ito, and S. Nagataki, Correlation between Thyroid Stimulators and 3, 5, 3’- Triiodothyronine Suppressibility in Patients during Treatment for Hyperthyroidism with Thionamide Drugs: Comparison of Assays by Thyroid-Stimulating and Thyrotropin-Displacing Activities, J Clin Endocrinol Metab. 48: 706 (1979).
N. Yokoyama, M. Izumi, and S. Nagataki, Heterogeneity of Graves 1 IgG: Comparison of TSH Receptor Antibodies in Serum and in Culture Supernatants of Lymphocytes Transformed by EB Virus Infection, J Clin Endocrinol Metab. (in press).
S. Nagataki, Pathogenic Factors of Graves 1 disease, in: “Current problems in Thyroid reseach,” N. Ui, K. Torizuka, S. Nagataki, and K. Miyai, ed., Excerpta Medica, Amsterdam-Oxford-Princeton (1982).
N. Hamada, T. Okabe, K. Kubota, S.C. Chiu, H. Uchimura, T. Mimura, K. Ito, and S. Nagataki, Chronic Effect of TSH on Human Thyroid Tissue in Organ Culture, Proc Soc Exp Biol Med. 172: 153 (1983).
S. Yamashita, M. Izumi, and S. Nagataki, Specific stimulatory effects of Graves’ IgG on the release of triiodothyronine from the patients’ own thyroids, Acta Endocrinol. 112: 204 (1986).
M. Londei, G.F. Bottazzo, and M. Feldman, Human T-Cell Clones from Autoimmune Thyroid Glands: Specific Recognition of Autologous Thyroid Cells, Science. 228: 85 (1985).
T. Hanafusa, L. Chiovato, D. Doniach, R. Pujol-Borrell, R.C.G. Russell, G.F. Bottazzo, Aberrant expression of HLA-DR antigen on thyrocytes in Graves’ disease: relevance for autoimmunity, Lancet. 2: 1111 (1983).
M. Matsunaga, K. Eguchi, T. Fukuda, A. Kurata, H. Tezuka, C. Shimomura, T. Otsubo, N. Ishikawa, K. Ito, and S. Nagataki, Class II Major Histocompatibility Complex Antigen Expression and Cellular Interaction in Thyroid Glands of Graves’ Disease, J Clin Endocrinol Metab. 62: 723 (1986).
H. Tamai. H. Uno, Y. Hirota, S. Matsubayashi, K. Kuma, H. Matsumoto, L.F. Kumagai, T. Sasazuki, and S. Nagataki, Immunogenetics of Hashimoto’s and Graves’ Diseases, J Clin Endocrinol Metab. 60: 62 (1985).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Plenum Press, New York
About this chapter
Cite this chapter
Nagataki, S. (1987). Pathogenic Roles of TSH-Receptor Antibodies in Graves’ Disease. In: Pinchera, A., Ingbar, S.H., McKenzie, J.M., Fenzi, G.F. (eds) Thyroid Autoimmunity. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0945-1_8
Download citation
DOI: https://doi.org/10.1007/978-1-4613-0945-1_8
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8258-7
Online ISBN: 978-1-4613-0945-1
eBook Packages: Springer Book Archive