Thyroid Growth Blocking Antibodies in Congenital Hypothyroidism
The causes of transient and permanent congenital hypothyroidism (CH) have not been entirely clarified, although there is increasing evidence that these diseases might be the result of an Immunological disorder. Thyroid growth blocking antibodies (TGBAb), detected in the sera of affected infants and their mothers, might suggest that the development and maturation of the fetal thyroid gland might be suppressed by these antibodies. Recently, Drexhage et al. 1 described TGBAb in patients with primary myxedema. Applying the same technique, van der Gaag et al. 2 detected thyroid growth blocking antibodies in about 50% of infants with congenital hypothyroidism.
KeywordsCongenital Hypothyroidism Thymidine Uptake Affected Infant Trichloroacetic Acid Solution Human Thyroid Cell
Unable to display preview. Download preview PDF.