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Thyroid Growth Blocking Antibodies in Congenital Hypothyroidism

  • H. Peters
  • U. Bogner
  • G. Holl
  • A. Grueters
  • R. Finke
  • H. Schleusener

Abstract

The causes of transient and permanent congenital hypothyroidism (CH) have not been entirely clarified, although there is increasing evidence that these diseases might be the result of an Immunological disorder. Thyroid growth blocking antibodies (TGBAb), detected in the sera of affected infants and their mothers, might suggest that the development and maturation of the fetal thyroid gland might be suppressed by these antibodies. Recently, Drexhage et al. 1 described TGBAb in patients with primary myxedema. Applying the same technique, van der Gaag et al. 2 detected thyroid growth blocking antibodies in about 50% of infants with congenital hypothyroidism.

Keywords

Congenital Hypothyroidism Thymidine Uptake Affected Infant Trichloroacetic Acid Solution Human Thyroid Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • H. Peters
    • 1
  • U. Bogner
    • 1
  • G. Holl
    • 1
  • A. Grueters
    • 2
  • R. Finke
    • 1
  • H. Schleusener
    • 1
  1. 1.Endocrine Departments of the MedicalPediatric Clinics of the Free University of BerlinGermany
  2. 2.Pediatric Clinics of the Free University of BerlinGermany

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