Antiidiotypic Blocking of Graves′ Disease Biologic Activity with Autologous Sera But Not Consistently with Homologous Sera: Evidence for Polyclonality of Thyroid Receptor Antibodies (Trab)
Although there is multiple evidence for the functional heterogeneity and polyclonality of TRAb (1 - 3) both statements are questioned by some investigators (4, 5). Furthermore there is growing evidence for an idiotypic-antiidiotypic regulation of Graves disease and other autoimmune diseases (6, 7).
KeywordsGrave Disease Biologic Parameter Nuclear Volume Functional Heterogeneity Thyroid Epithelial Cell
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- 1.S.H. Ingbar (1986) The role of antibodies and other humoral factors in the pathogenesis of Graves disease In: the thyroid and autoimmunity, H.A. Drexhage, W.M. Wiersinga ed,Excerpta MEDICAGoogle Scholar
- 3.J. Worthington, R.L. Himsworth, P.G.H. Byfield (1986) Isolation of both agonist and nonagonist Graves immunoglobulins from the sera of individual patients. In the thyroid and autoimmunity. H.A. Drexhage, W.M. Wiersinga ed, Excerpta MEDICAGoogle Scholar
- 4.M. Zakarija, S.Jin, J.M. McKenzie(1986) Support for the identity of thyroid stimulating antibody (TSAb) and thyroid growth stimulating IgG (TGI) in Graves’ disease. 61st meeting of the Ameri can Thyroid Association, Sept 11-13, Abstract 34.Google Scholar
- 5.B.S. Hawe, N.R. Farid (1986) An antiidiotypic antibody against Graves’ IgG Advances in thyroidology, International Symposium, Lübeck, Germany, Oct 2 - 4th, Abstract 16.Google Scholar