The Effect of Thyroid Stimulating Immunoglobulins (TSI) on Thyroid Camp: Comparison with TSH Activity
Thyroid stimulating immunoglobulins (TSI) are believed to act by interacting with TSH receptor as indicated by the ability of TSI to inhibit radiolabeled TSH binding to its receptor.1 However a good correlation between the inhibition of TSH binding and TSI biological activity is not always demonstrable.2 Moreover, other antibodies interact with the TSH receptor and block TSH activity but do not have any agonist activity. 3 The possibility remains, therefore, that TSI binds to the TSH receptor on a site different from the TSH-binding site, or alternatively that TSI may influence the TSH receptor via an allosteric mechanism.
KeywordsIodine Adenosine Iodide Epinephrine Propranolol
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