The Effect of Thyroid Stimulating Immunoglobulins (TSI) on Thyroid Camp: Comparison with TSH Activity

  • Sebastiano Filetti
  • Giuseppe Damante
  • Daniela Foti
  • Rosaria Catalfamo
  • Riccardo Vigneri

Abstract

Thyroid stimulating immunoglobulins (TSI) are believed to act by interacting with TSH receptor as indicated by the ability of TSI to inhibit radiolabeled TSH binding to its receptor.1 However a good correlation between the inhibition of TSH binding and TSI biological activity is not always demonstrable.2 Moreover, other antibodies interact with the TSH receptor and block TSH activity but do not have any agonist activity. 3 The possibility remains, therefore, that TSI binds to the TSH receptor on a site different from the TSH-binding site, or alternatively that TSI may influence the TSH receptor via an allosteric mechanism.

Keywords

Iodine Adenosine Iodide Epinephrine Propranolol 

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • Sebastiano Filetti
    • 1
  • Giuseppe Damante
    • 1
  • Daniela Foti
    • 1
  • Rosaria Catalfamo
    • 1
  • Riccardo Vigneri
    • 1
  1. 1.Cattedra di EndocrinologiaUniversita di CataniaCataniaItaly

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