The Effect of Thyroid Stimulating Immunoglobulins (TSI) on Thyroid Camp: Comparison with TSH Activity
Thyroid stimulating immunoglobulins (TSI) are believed to act by interacting with TSH receptor as indicated by the ability of TSI to inhibit radiolabeled TSH binding to its receptor.1 However a good correlation between the inhibition of TSH binding and TSI biological activity is not always demonstrable.2 Moreover, other antibodies interact with the TSH receptor and block TSH activity but do not have any agonist activity. 3 The possibility remains, therefore, that TSI binds to the TSH receptor on a site different from the TSH-binding site, or alternatively that TSI may influence the TSH receptor via an allosteric mechanism.
KeywordsAdenylate Cyclase Thyroid Tissue Thyroid Cell cAMP Content Cellular cAMP
Unable to display preview. Download preview PDF.
- 6.P. Vitti, L. Chiovato, P. Ceccarelli, A. Lombardi, M. Novaes, G. F. Fenzi A. Pinchera, Thyroid-stimulating antibody mimics thyrotropin in its ability to desensitize the adenosine 31,51-monophosphate response to acute stimulation in continuously cultured rat thyroid cells (FRT-L5). J. Clin. Endocrinol. Metab. 63:454 (1986)PubMedCrossRefGoogle Scholar