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Circulatory Thyroglobulin Threshold in Suppressor Activation

  • M. Kong Yi-chi
  • Mark Lewis
  • Alvaro A. Giraldo
  • Brian E. Fuller

Abstract

Murine experimental autoimmune thyroiditis (EAT) has served as a model for Hashimoto’s thyroiditis, and mouse thyroglobulin (MTg) as a model for self antigen of the thyroid in genetically susceptible (MHC-associated) individuals1-. EAT is induced readily when autoreactive inducer/helper T cells (TI) are stimulated by MTg given repeatedly2 or with an adjuvant, such as lipopolysaccharide (LPS)3. However, the preinjection of 100-200 yg MTg or thyroid-regulating hormones (TSH or TRH) activates suppressor mechanisms which interfere with EAT induction4. Both regimens elevate the levels of circulating MTg for a short interval.

Keywords

Osmotic Pump Autoantibody Titer Activate Suppressor Cells4 Mononuclear Phagocytic System Log2 Titer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • M. Kong Yi-chi
    • 1
  • Mark Lewis
    • 1
  • Alvaro A. Giraldo
    • 2
  • Brian E. Fuller
    • 1
  1. 1.Department of Immunology and MicrobiologyWayne State Univ. Sch. of Med.USA
  2. 2.Div. of Immunopathol.St. John Hosp.DetroitUSA

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