Circulatory Thyroglobulin Threshold in Suppressor Activation

  • M. Kong Yi-chi
  • Mark Lewis
  • Alvaro A. Giraldo
  • Brian E. Fuller


Murine experimental autoimmune thyroiditis (EAT) has served as a model for Hashimoto’s thyroiditis, and mouse thyroglobulin (MTg) as a model for self antigen of the thyroid in genetically susceptible (MHC-associated) individuals1-. EAT is induced readily when autoreactive inducer/helper T cells (TI) are stimulated by MTg given repeatedly2 or with an adjuvant, such as lipopolysaccharide (LPS)3. However, the preinjection of 100-200 yg MTg or thyroid-regulating hormones (TSH or TRH) activates suppressor mechanisms which interfere with EAT induction4. Both regimens elevate the levels of circulating MTg for a short interval.


Osmotic Pump Autoantibody Titer Activate Suppressor Cells4 Mononuclear Phagocytic System Log2 Titer 
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Copyright information

© Plenum Press, New York 1987

Authors and Affiliations

  • M. Kong Yi-chi
    • 1
  • Mark Lewis
    • 1
  • Alvaro A. Giraldo
    • 2
  • Brian E. Fuller
    • 1
  1. 1.Department of Immunology and MicrobiologyWayne State Univ. Sch. of Med.USA
  2. 2.Div. of Immunopathol.St. John Hosp.DetroitUSA

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