Circulatory Thyroglobulin Threshold in Suppressor Activation
Murine experimental autoimmune thyroiditis (EAT) has served as a model for Hashimoto’s thyroiditis, and mouse thyroglobulin (MTg) as a model for self antigen of the thyroid in genetically susceptible (MHC-associated) individuals1-. EAT is induced readily when autoreactive inducer/helper T cells (TI) are stimulated by MTg given repeatedly2 or with an adjuvant, such as lipopolysaccharide (LPS)3. However, the preinjection of 100-200 yg MTg or thyroid-regulating hormones (TSH or TRH) activates suppressor mechanisms which interfere with EAT induction4. Both regimens elevate the levels of circulating MTg for a short interval.
KeywordsOsmotic Pump Autoantibody Titer Activate Suppressor Cells4 Mononuclear Phagocytic System Log2 Titer
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