Some Aspects of Cell Mediated Autoimmunity in Endemic Nodular Goitre
The diagnosis of autoimmune thyroid disease (ATD), when suspected as a result of clinical, hormonal, instrumental (U.S., scintigraphy), and immunological findings, may be confirmed by conventional hystology or immunochemical stainings also applicable to tissue or simple cells obtained by fine needle biopsy. This has been reported by several authors who investigated lymphoid cell subsets from thyroids of patients with suspected ATD1,2,3,4. In this present work, and in previous works, we looked for the presence and possibly the meaning of lymphoid tissue infiltrating the thyroid (LI) of goitrous patients living in an iodine deficient area. In these patients frequently we found high prevalence of antithyroid autoantibodies at low title and histological findings of focal thyroiditis.
KeywordsAutoimmune Thyroid Disease Follicular Adenoma Fine Needle Biopsy Immunochemical Staining Toxic Goitre
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- 1.T.H. Totterman, Thyroid infiltrating, immunocompetent cells in human autoimmune thyroid disease: subclass distribution and in vitro functions. Academic Dissertation, Helsinki, Finland (1978)Google Scholar
- 3.G. Aichinger, H. Fill and G. Wick, In situ immune complexes, lymphocyte subpopulation and HLA-DR positive epithelial cells in Hashimoto Thyroiditis, Laboratory Investigation, 52, 2:132 (1985)Google Scholar
- 5.R. Volpe and V.V. Row, Role of antigen specific suppressor T-lymphocytes in the pathogenesis of autoimmune thyroid disease, in: Autoimmunity and the thyroid, P.G. Walfish, ed., Academic Press, Inc., (1985)Google Scholar
- 6.I. Todd, R. Pujol-Borrell, M. Londei, M. Feldman and G.F. Bottazzo, Inappropriate HLA class II expression on epithelial cells: consolidation and progress, in: The thyroid and autoimmunity, H.A. Drexhage, W.M. Wiersinga, ed., Excerpta Medica, International Congress Series, 711 (1986)Google Scholar