Treatment of Graves’ Ophthalmopathy by Retrobulbar Corticosteroids Associated With Orbital Cobalt Radiotherapy
Combined therapy with systemic corticosteroids and orbital cobalt radiotherapy (RT) has proven an effective method for treatment of severe Graves’ ophthalmopathy (1). The use of large doses of systemic corticosteroids is potentially risky. In more than 100 patients treated so far at our Institution with systemic corticosteroids either alone or in combination with radiotherapy, relevant side effects have been observed in 4 cases: one patient had an increase of intraocular tension, one showed depressive psychosis, one developed diabetic syndrome requiring insulin, and one had infective encephalitis within the first month of treatment (2). This prompted us to assess the therapeutic effectiveness of retrobulbar long-acting corticosteroids (RBC) in substitution for systemic corticosteroids in the combined therapy in a group of 44 consecutive patients with active Graves’ ophthalmopathy.
KeywordsOptic Neuropathy Systemic Corticosteroid Extraocular Muscle Active Grave Methylprednisolone Acetate
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