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Extracellular Matrix Effects on Mammary Cell Behavior

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Cellular and Molecular Biology of Mammary Cancer

Abstract

Developmental biologists have long recognized that the extracellular matrix (ECM) plays a vital role in various developmental processes such as tissue morphogenesis and cytodifferentiation (1,2,3). Expression of the proliferative, morphogenetic and functional potentialities of the mammary epitheliumin vivo and in culture are clearly influenced by the ECM (4,5). The mechanistic details of how the ECM affects mammary epithelial cell behavior remain to be defined. As the ECM supports the mammary epithelium in vivo includes both acellular and cellular domains, ECM-mediated effects are likely to include interactions between different acellular ECM components, between cells and acellular ECM components and between different cell types. Additionally, such interactions must be coupled to the hormonal and growth factor requirements known to exist for expression of the mammary cell phenotype.

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Authors and Affiliations

  1. Department of Microbiology, The University of Texas Dental Branch, Houston, TX, 77225, USA

    Elisa M. Durban

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  1. Elisa M. Durban
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Editors and Affiliations

  1. Baylor College of Medicine, Houston, Texas, USA

    Daniel Medina

  2. National Cancer Institute, Bethesda, Maryland, USA

    William Kidwell  & Elizabeth Anderson  & 

  3. Michigan Cancer Foundation, Detroit, Michigan, USA

    Gloria Heppner

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© 1987 Plenum Press, New York

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Durban, E.M. (1987). Extracellular Matrix Effects on Mammary Cell Behavior. In: Medina, D., Kidwell, W., Heppner, G., Anderson, E. (eds) Cellular and Molecular Biology of Mammary Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0943-7_6

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  • DOI: https://doi.org/10.1007/978-1-4613-0943-7_6

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