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Current Concepts of Selenium and Mammary Tumorigenesis

  • Chapter
Cellular and Molecular Biology of Mammary Cancer

Abstract

The essentiality of selenium as a trace element was recognized in 1957 (1). On the biochemical level, selenium has long been known to have an antagonistic effect on lipid peroxidation. However, it was not until 1973 that the molecular basis of the antioxidant function of selenium was established. The milestone publication from Hoekstra’s laboratory reported that glutathione peroxidase, an enzyme that metabolizes peroxides, contains selenium as a prosthetic group (2). The activity of glutathione peroxidase in tissues is directly related to the availability of dietary selenium; thus low enzyme activity is invariably associated with selenium deficiency (3). Although other selenium-containing proteins have since been identified in eukaryotic cells (4,5), glutathione peroxidase is the only selenoprotein to date that is functionally characterized.

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Authors and Affiliations

  1. Department of Breast Surgery, Roswell Park Memorial Institute, Buffalo, NY, 14263, USA

    Clement Ip

  2. Department of Cell Biology, Baylor College of Medicine, Houston, TX, 77030, USA

    Daniel Medina

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  1. Clement Ip
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Editors and Affiliations

  1. Baylor College of Medicine, Houston, Texas, USA

    Daniel Medina

  2. National Cancer Institute, Bethesda, Maryland, USA

    William Kidwell  & Elizabeth Anderson  & 

  3. Michigan Cancer Foundation, Detroit, Michigan, USA

    Gloria Heppner

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Ip, C., Medina, D. (1987). Current Concepts of Selenium and Mammary Tumorigenesis. In: Medina, D., Kidwell, W., Heppner, G., Anderson, E. (eds) Cellular and Molecular Biology of Mammary Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0943-7_26

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  • DOI: https://doi.org/10.1007/978-1-4613-0943-7_26

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