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Cellular and Molecular Biology of Mammary Cancer pp 399–417Cite as

Role of Differentiation on Transformation of Human Breast Epithelial Cells

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Abstract

There is increasing evidence that the fate of tumor development is determined by a conglomerate of circumstances acting at the time of initiation of the carcinogenic event (1). Tumors developed as a response to either a chemical, physical or biological insult do not arise at random, but require specific conditions of the host, of the target organ and of a specific target structure within that organ for the neoplastic phenomenon to take place (1,2).

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Authors and Affiliations

  1. Department of Pathology, Michigan Cancer Foundation, Detroit, MI, 48201, USA

    Jose Russo & Irma H. Russo

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  1. Jose Russo
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  2. Irma H. Russo
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Editors and Affiliations

  1. Baylor College of Medicine, Houston, Texas, USA

    Daniel Medina

  2. National Cancer Institute, Bethesda, Maryland, USA

    William Kidwell  & Elizabeth Anderson  & 

  3. Michigan Cancer Foundation, Detroit, Michigan, USA

    Gloria Heppner

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© 1987 Plenum Press, New York

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Russo, J., Russo, I.H. (1987). Role of Differentiation on Transformation of Human Breast Epithelial Cells. In: Medina, D., Kidwell, W., Heppner, G., Anderson, E. (eds) Cellular and Molecular Biology of Mammary Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0943-7_22

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  • DOI: https://doi.org/10.1007/978-1-4613-0943-7_22

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