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Prostaglandins in Breast Cancer

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Cellular and Molecular Biology of Mammary Cancer

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Abstract

The prostaglandins (PGs) are a group of lipids synthesized from arachidonic acid via the cyclooxygenase pathway; other cyclooxygenase products, including thromboxane and prostacyclin, as well as lipoxygenase- dependent products of arachidonate, which include the leukotrienes and hydroxyeicosatetraenoic acids, are collectively referred to as eicosanoids (reviewed in 1). While interest in all eicosanoids has increased vis a vis cancer (reviewed in 2), this review will focus on the primary prostaglandins, i.e., 20-carbon, unsaturated lipids, designated by letters, e.g., PGE2, PGF2α , PGD2, etc. PGE2 has been studied most extensively.

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Authors and Affiliations

  1. Department of Immunology, Michigan Cancer Foundation, 110 East Warren Avenue, Detroit, Michigan, 48201, USA

    Amy M. Fulton

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  1. Amy M. Fulton
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Editors and Affiliations

  1. Baylor College of Medicine, Houston, Texas, USA

    Daniel Medina

  2. National Cancer Institute, Bethesda, Maryland, USA

    William Kidwell  & Elizabeth Anderson  & 

  3. Michigan Cancer Foundation, Detroit, Michigan, USA

    Gloria Heppner

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© 1987 Plenum Press, New York

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Fulton, A.M. (1987). Prostaglandins in Breast Cancer. In: Medina, D., Kidwell, W., Heppner, G., Anderson, E. (eds) Cellular and Molecular Biology of Mammary Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0943-7_15

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  • DOI: https://doi.org/10.1007/978-1-4613-0943-7_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-306-42761-9

  • Online ISBN: 978-1-4613-0943-7

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