Skip to main content
SpringerLink
Log in
Book cover

Endothelial Cell Biology in Health and Disease pp 69–104Cite as

Receptor-Mediated Transcytosis of Plasma Molecules by Vascular Endothelium

  • Chapter

Abstract

Vascular endothelium is endowed with a wide spectrum of functions among which of paramount importance is the exchange of substances between blood and tissues. Endothelium possesses all the basic properties of an epithelium highly specialized for transport: it is polarized, metabolically very active, and exhibits a structure and biochemistry subtly differentiated according to the activities of the tissue in which it resides.8, 107 As demonstrated by work carried out especially in the last decade, the participation of endothelial cells in the plasma-interstitial fluid exchanges is a more refined and dynamic phenomenon than initially considered.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adams, C. J., Maurcy, K. M., and Storrie, B., 1982, Exocytosis of pinocytic contents by Chinese hamster ovary cells, J. Cell Biol. 93:632–637.

    Article  Google Scholar 

  2. Antohe, F., Heltianu, C., andSimionescu, N., 1987, Further evidence for the distribution and nature of histamine receptors on microvascular endothelium, Microcirc. Endothel. Lymph. 3:163–185.

    Google Scholar 

  3. Baker, D. P., Van Lenten, B. J., Fogelman, A. M., Edwards, P. A., Kean, C., and Berliner, J. A., 1984, LDL, scavenger, (3-VLDL receptors on aortic endothelial cells, Arteriosclerosis 4:248–255.

    Article  PubMed  CAS  Google Scholar 

  4. Baldwin, A. L., andChien, S.,1984, Endothelial transport of anionized and cationized ferritin in the rabbit thoracic aorta and vasa vasorum, Arteriosclerosis 4:372–382.

    Article  PubMed  CAS  Google Scholar 

  5. Baldwin, A. L., andChien, S., 1985, Effect of plasma proteins on endothelial binding and vesicle loading of anionized ferritin in rabbit aorta, Arteriosclerosis 5:451–458.

    Google Scholar 

  6. Baldwin, A. L., and Chien, S., 1985, Regulation of aortic endothelial vesicular uptake of cationized ferritin by plasmalemmal binding, Atherosclerosis 55:233–245.

    Article  PubMed  CAS  Google Scholar 

  7. Becker, C. G., and Harpel, C. P.,1976,Alpha-2-macroglobulin on human vascular endothelium, J. Exp. Med. 144:1–9.

    Article  PubMed  CAS  Google Scholar 

  8. Betz, A. L., 1985,Epithelial properties of brain capillary endothelium, Fed. Proc. 44:2614–2615.

    PubMed  CAS  Google Scholar 

  9. Bignon, J., Chahinian, P., Feldman, G., and Sapin, C., 1975, Ultrastructural immunoperoxidase demonstration of autologous albumin in the alveolar capillary membrane and in the alveolar lining material in normal rats, J. Cell Biol. 64:503–509.

    Article  PubMed  CAS  Google Scholar 

  10. Blomhoff, R., Eskild, W., and Berg, T., 1984,Endocytosis of formaldehyde-treated serum albumin via scavenger pathway in liver endothelial cells, Biochem. J. 218:81–86.

    PubMed  CAS  Google Scholar 

  11. Boyles, J., L’Hernault, N., Laks, H., and Palade, G. E., 1981,Evidence for vesicular shuttle in heart capillaries,J. Cell Biol. 91:418a.

    Google Scholar 

  12. Brandes, R., Okner, R. K., Weisiger, R. A., and Lysenko, N., 1982, Specific and saturable binding of albumin to rat adipocytes: Modulation by epinephrine and possible role in free fatty acid transfer,Biochem. Biophys. Res. Commun. 105:821–827.

    Article  PubMed  CAS  Google Scholar 

  13. Bundgaard, M., 1984, The three dimensional organization of tight junctions in a capillary endothelium revealed by serial-section electron microscopy, J. Ultrastruct. Res. 88:1–17.

    Article  PubMed  CAS  Google Scholar 

  14. Bundgaard, M., Hagman, P., and Crone, C., 1983, The three dimensional organization of plasmalemmal vesicular profiles in the endothelium of rat heart capillaries,Microvasc. Res. 25:358— 368.

    Article  Google Scholar 

  15. Casley-Smith, J. R., 1985,Vesicular form and fusion as revealed by freeze-immobilization and stereoscopy of semi-thin sections: Implications for permeation via these structures, Prog. Appl. Microcirc. 9:6–20.

    Google Scholar 

  16. Chang, R. L. S., Dean, W. M., Robertson, C. R., and Brenner, B. M., 1975, Permselectivity of the glomerular capillary wall. III. Restricted transport of polyanions, Kidney Int. 8:212–218.

    Article  PubMed  CAS  Google Scholar 

  17. Chien, S., Fan, F-C., Lee, M. A. L., and Handley, D. A., 1984, Effects of arterial pressure on endothelial transport of macromolecules,Biorheology 21:631–641.

    PubMed  CAS  Google Scholar 

  18. Clough, G., 1982, The steady state transport of cationized ferritin by endothelial cell vesicles,J. Physiol. (London) 328:389–401.

    PubMed  CAS  Google Scholar 

  19. Clough, G., and Michel, C. C., 1981, The role of vesicles in the transport of ferritin through frog endothelium,J. Physiol. (London) 315:127–148.

    PubMed  CAS  Google Scholar 

  20. Copley, A. L., 1983, The endo-endothelial fibrin lining: A historical account, Thromb. Res. 5 (Suppl.):l–26.

    Google Scholar 

  21. Crone, C., 1986, Modulation of solute permeability in microvascular endothelium, Fed. Proc. 45:77–83.

    PubMed  CAS  Google Scholar 

  22. Curry, F.-R.E., 1982, The effect of charge on the transport of intermediate sized protein probes across the capillary wall, in: The Pathogenicity ofCationic Proteins (P.P.Lambert, P. Bergmann, and R. Beauwens, eds.), Raven Press, New York, pp 120–124.

    Google Scholar 

  23. Curry, F.-R. E., and Michel, C. C., 1980, A fiber matrix theory of capillary permeability,Microvasc. Res. 20:96–99.

    Article  PubMed  CAS  Google Scholar 

  24. Danon, D., and Skutelsky, E., 1979, Endothelial surface charge and its positive relationship to thrombogenesis,Ann. N.Y. Acad. Sci. 275:47–63.

    Article  Google Scholar 

  25. Dernovsek, K. D., and Bar, R. S., 1985, Processing of cell bound insulin by capillary and macrovascular endothelial cells in culture,Am. J. Physiol. 248:E244–E251.

    PubMed  CAS  Google Scholar 

  26. Dernovsek, K. D., Bar, R. S., Ginsberg, B. H., and Lioubin, M. N., 1984, Rapid transport of biologically intact insulin through cultured endothelial cells,J. Clin. Endocrinol. Me tab. 58:761–763.

    Article  Google Scholar 

  27. Devenny, J. J., and Wagner, R. C., 1985, Transport of immunoglobulin G by endothelial vesicles in isolated capillaries, Microcirc. Endothel. Lymph. 2:15–26.

    CAS  Google Scholar 

  28. Fishman, J. B., Andrahan, J. V., Connor, J., Dickey, B. F., and Fine, R. E., 1985, Receptormediated transcytosis of transferrin across the blood brain barrier, J. Cell Biol. 101:423a.

    Google Scholar 

  29. Forker, E. L., and Luxon, B. A., 1983, Albumin-mediated transport of rose bengal by perfused rat liver,J. Clin. Invest. 72:1764–1771.

    Article  PubMed  CAS  Google Scholar 

  30. Fr0kjaer-Jensen, J., 1980, Three-dimensional organization of plasmalemmal vesicles in endothelial cells: An analysis by serial sectioning of frog mesenteric capillaries,J. Ultrastruct. Res. 73:9–20.

    Article  PubMed  CAS  Google Scholar 

  31. Fujimoto, T., and Singer, S. J., 1986, Immunocytochemical studies of endothelial cells in vivo. I. The presence of desmin only, or of desmin plus vimentin, or vimentin only, in the endothelial cells of different capillaries of the adult chicken, J. Cell Biol. 103:2775–2787,

    Article  PubMed  CAS  Google Scholar 

  32. Galis, Z., Ghitescu, L., Simionescu, M., and Simionescu, N., 1987,Fatty acid binding to albumin increases its uptake and transcytosis by the lung capillary endothelium, J. Cell Biol. 105:612

    Google Scholar 

  33. Ghinea, N., and Hasu, M., 1986, Charge effect on binding, uptake and transport of ferritin through fenestrated endothelium, J. Submicrosc. Cytol. 18:647–659.

    PubMed  CAS  Google Scholar 

  34. Ghinea, N., and Simionescu, N., 1985, Anionized and cationized hemeundecapeptides as probes for cell surface charge and permeability studies: Differentiated labeling of endothelial plasmalemmal vesicles, J. Cell Biol. 100:606–612.

    Article  PubMed  CAS  Google Scholar 

  35. Ghitescu, L., and Fixman, A., 1984, Surface charge distribution on the endothelial cell of liver sinusoids, J. Cell Biol. 99:639–647.

    Article  PubMed  CAS  Google Scholar 

  36. Ghitescu, L., Fixman, A., Simionescu, M., and Simionescu, N., 1985, Albumin is transported through capillaries with continuous endothelium by receptor-mediated transcytosis, J. Cell Biol. 101:424a.

    Google Scholar 

  37. Ghitescu, L., Fixman, A., Simionescu, M., and Simionescu, N., 1986, Transendothelial transport of serum albumin in the aorta, coronaries and heart valves of experimental hypercholesterolemic hamsters, in: XVIth International Congress of the International Academy of Pathology, Vienna, Abstracts Volume,69.

    Google Scholar 

  38. Ghitescu, L., Fixman, A., Simionescu, M., and Simionescu, N., 1986,Specific binding sites for albumin restricted to plasmalemmal vesicles of continuous capillary endothelium: Receptor-mediated transcytosis, J. Cell Biol 102:1304-1311.

    Article  PubMed  CAS  Google Scholar 

  39. Ghitescu, L., Fixman, A., Simionescu, M., and Simionescu, N binding sites for albumin restricted to plasmalemmal vesicles of continuous capillary endothelium: Receptor-mediated transcytosis, J. Cell Biol 102:1304–1311.

    Google Scholar 

  40. Ghitescu, L., Fixman, A., Simionescu, M., and Simionescu, N., 1986, Differentiated uptake and transcytosis of albumin by the continuous endothelium of successive vascular segments, J. Cell Biol. 103:449a.

    Google Scholar 

  41. Ghitescu, L., Galis, Z., Simionescu, M., and Simionescu, N., 1987, Diferentiated uptake and transcytosis of albumin in successive vascular segments, Circ. Res. (in press).

    Google Scholar 

  42. Gorin, A. B., and Stewart, P. A., 1979, Differential permeability of endothelial and epithelial barriers to albumin flux, J. Appl. Physiol. 47:1315–1324.

    PubMed  CAS  Google Scholar 

  43. Gorog, P., and Born, G. V. R., 1982,Increased uptake of circulating low density lipoproteins and fibrinogen by arterial walls after removal of sialic acid from the endothelial surface, Br. J. Exp. Pathol. 63:447–451.

    PubMed  CAS  Google Scholar 

  44. . Grotte, G., 1956, Passage of dextran molecules across the blood-lymph barrier, Acta Clin. Scand. Suppl. 211:1–84.

    CAS  Google Scholar 

  45. Haraldsson, H., and Rippe, B., 1985, Serum factors other than albumin are needed for the maintenance of normal capillary permselectivity in rat hindlimb muscle, Acta Physiol. Scand. 123:427–436.

    Article  PubMed  CAS  Google Scholar 

  46. Hashida, R., Anamizu, C., Kimura, J., Ohkuma, S., Yoshida, Y., and Takano, T., 1986, Transcellular transport of lipoprotein through arterial endothelial cells in monolayer culture, Cell Struct. Funct. 11:31–42.

    Article  PubMed  CAS  Google Scholar 

  47. Heltianu, C., Simionescu, M., and Simionescu, N., 1982, Histamine receptors of the microvascular endothelium revealed in situ with a histamine-ferritin conjugate: Characteristic high affinity binding sites in venules, J. Cell Biol. 93:357–364.

    Article  PubMed  CAS  Google Scholar 

  48. Herzog, V., 1983, Transcytosis in thyroid follicular cells, J. Cell Biol. 97:607–617.

    Article  PubMed  CAS  Google Scholar 

  49. Horiuchi, S., Murakami, M., Takata, K., and Morino, Y., 1986,Scavenger receptor for aldehydemodified proteins, J. Biol. Chem. 261:4962–4966.

    PubMed  CAS  Google Scholar 

  50. Horiuchi, S., Takata, K., and Morino, Y., 1985, Characterization of a membrane associated receptor from rat sinusoidal liver cells that binds formaldehyde-treated serum albumin, J. Biol. Chem. 260:475–481.

    PubMed  CAS  Google Scholar 

  51. Horiuchi, S., Takata, K., and Morino, Y., 1985, Purification of a receptor for formaldehydetreated serum albumin from rat liver, J. Biol. Chem. 260:482–488.

    PubMed  CAS  Google Scholar 

  52. Horvat, R., Hovorka, A., Dekan, G., Poczewski, H., and Keijaschki, D., 1986, Endothelial cell membranes contain podocalyxin—the major sialoprotein of visceral glomerular epithelial cells,J. Cell Biol. 102:484–491.

    Article  PubMed  CAS  Google Scholar 

  53. Huang, T. W., and Langlois, J. C., 1985, Podoendin—a new cell surface protein of the podocyte and endothelium, J. Exp. Med. 162:245–267.

    Article  PubMed  CAS  Google Scholar 

  54. Hutter, J. F., Piper, H. M., and Spieckermann, P. G.,1984, Kinetic analysis of myocardial fatty acid oxidation suggesting an albumin receptor mediated uptake process, J. Mol. Cell. Cardiol. 16:219–226.

    Article  PubMed  CAS  Google Scholar 

  55. Hutter, J. F., Piper, H. M., and Spieckermann, P. G., 1984, Myocardial fatty acid oxidation: Evidence for an albumin-receptor-mediated membrane transfer of fatty acids, Basic Res. Cardiol. 79:274–282.

    Article  PubMed  CAS  Google Scholar 

  56. Irie, S., and Tavassoli, M., 1986, Liver endothelium desialates ceruloplasmin, Biochem. Biophys. Res. Commun. 140:94–100.

    Article  PubMed  CAS  Google Scholar 

  57. Jefferies, W. A., Brandon, M. R., Hunt, S. V., Williams, A. F., Gatter, K. C., and Mason, D. Y., 1984, Transferrin receptor on endothelium of brain capillaries, Nature 312:162–163.

    Article  PubMed  CAS  Google Scholar 

  58. Johansson, B. R., 1979, Capillary permeability to interstitial microinjections of macromolecules and influence of capillary hydrostatic pressure on endothelial ultrastructure, Acta Physiol. Scand. 463:45–50.

    CAS  Google Scholar 

  59. Johansson, B. R., Karlsson, R., and Bagge, U., 1983, Ultrastructural observations on endothelial cell vesicles after horseradish peroxidase microinjection into blood and dextran-perfused microvessels of rat mesentery, Int. J. Microcirc. Clin. Exp. 2:157–169.

    PubMed  CAS  Google Scholar 

  60. Joris, I., Majno, G., and Ryan, G. B., 1972, Endothelial contraction in vivo: A study of the rat mesentery,Virchows Arch. B. 12:73–83.

    CAS  Google Scholar 

  61. Kataoka, M., and Tavassoli, M., 1984, Ceruloplasmin receptors in liver cell suspensions are limited to the endothelium, Exp. Cell Res. 155:232–240.

    Article  PubMed  CAS  Google Scholar 

  62. Kataoka, M., and Tavassoli, M., 1985, The role of liver endothelium in the binding and uptake of ceruloplasmin: Studies with colloidal gold probe,J. Ultrastruct. Res. 90:194–202.

    Article  PubMed  CAS  Google Scholar 

  63. King, G. L., Jialal, I., Buchwald, S., and Johnson, S., 1984, Receptor-mediated uptake and transport of insulin by endothelial cells,Diabetes 33(Suppl. 1):9A.

    Article  Google Scholar 

  64. King, G. L., and Johnson, S. M., 1985, Receptor-mediated transport of insulin across endothelial cells, Science 227:1583–1586.

    Article  PubMed  CAS  Google Scholar 

  65. King, G. L., Johnson, S. M., and Jialal, I., 1985, Processing and transport of insulin by vascular endothelial cells: Effects of sulfonylurease on insulin receptors,Am. J. Med. 79:43–47.

    Article  PubMed  CAS  Google Scholar 

  66. Kurozumi, T., Imamura, T., Tanaka, K., Yae, Y., and Koga, S., 1984, Permeation and deposition of fibrinogen and low density lipoprotein in the aorta and cerebral artery of rabbits—Immuneelectron microscopic study, Br. J. Exp. Pathol.65:355–364.

    PubMed  Google Scholar 

  67. Lake, J. R., Licko, V., Van Dyke, R. W., and Scharschmidt, B. F., 1985, Biliary secretion of fluid-phase markers by the isolated perfused rat liver: Role of transcellular vesicular transport, J. Clin. Invest. 76:676–684.

    Article  PubMed  CAS  Google Scholar 

  68. Leabu, M., Ghinea, M., Muresan, V., Colceag, J., Hasu, M., and Simionescu, N., 1987, Cell surface chemistry of arterial endothelium and blood monocytes in the normolipidemic rabbit, J. Submicrosc. Cytol. 19:193–208.

    PubMed  CAS  Google Scholar 

  69. Lenkei, R., Onica, D., and Ghetie, V., 1977, Receptors for polymerized albumin on liver cells, Experientia 33:1046–684

    Article  PubMed  CAS  Google Scholar 

  70. . Machida, A., Shimoto, S., Ohnuma, H., Miyamoto, H., Baba, K., Oda, K., Nakamura, T., Miyakawa, Y., and Mayumi, M., 1983, A hepatitis B surface antigen polypeptide (P31) with the receptor for chimpanzee albumins,Gastroenterology 85:268–274.

    PubMed  CAS  Google Scholar 

  71. . Majno, G., Gilmore, V., and Leventhal, M., 1967, On the mechanism of vascular leakage caused by histamine-type mediators,Circ. Re. 21:833–847.

    CAS  Google Scholar 

  72. Majno, G., and Palade, G. E., 1961, Studies on inflammation. I. The effect of histamine and serotonin on vascular permeability: An electron microscopic study, J. Biophys. Biochem. Cytol. 11: 571–606.

    Article  PubMed  CAS  Google Scholar 

  73. Maratos-Flier, E., Yang-Kao, C. Y., and King, G. L., 1986,Receptor-mediated transcytosis of epidermal growth factor in MDCK cells, J. Cell Biol. 103:449a.

    Google Scholar 

  74. McGuire, P. C., and Twietmayer, T. A., 1985, Transcytosis of ferritin and increased production of subendothelial matrix components by aortic endothelial cells during the development of hypertension, Microcirc. Endothel. Lymph. 2:129–149.

    CAS  Google Scholar 

  75. Milici, A. J., Watrous, N. E., and Palade, G. E.,1986,Immunogold localization of exogenous albumin in murine myocardial capillaries, J. Cell Biol. 103:194a.

    Google Scholar 

  76. Mostov, K. E., and Simister, N. E., 1985,Transcytosis, Cell 43:389–390.

    Article  PubMed  CAS  Google Scholar 

  77. Muller, W. A., and Gimbrone, M. A., J r.,1986, Plasmalemmal proteins of cultured vascular endothelial cells exhibit apical-basal polarity: Analysis by surface-selective iodination, J. Cell Biolj. 103:2389–2402.

    Article  CAS  Google Scholar 

  78. Muresan, V., and Constantinescu, M. C., 1985, Distribution of sialoconjugates on the luminal surface of the endothelial cell in fenestrated capillaries of the pancreas,J. Histochem.Cytochem. 33:474–476.

    Article  PubMed  CAS  Google Scholar 

  79. Muresan, V., and Simionescu, N.,1984,Intracellular fate of a multivalent ligand covalently bound to cell surface components, in: International Cell Biology, 1984 (S. Seno and Y. Okada, eds.), Academic Press Japan, Inc., Tokyo, p. 334.

    Google Scholar 

  80. Nistor, A., and Simionescu, M., 1986, Uptake of low density lipoproteins by the hamster lung: Interactions with capillary endothelium,Am. Rev. Respir. Dis. 134:1266–1272.

    PubMed  CAS  Google Scholar 

  81. Ockner, R. K., Weisiger, R. A., and Gollan, J. L., 1983,Hepatic uptake of albumin-bound substances: Albumin receptor concept,Am. J. Physiol. 245:613–619

    Google Scholar 

  82. Olesen, S.-P., and Crone, C.,1984, Serotonin increases microvascular permeability in the brain, Int. J. Microcirc. Clin. Exp. 3:466.

    Google Scholar 

  83. Palade, G. E., 1960, Transport in quanta across the endothelium of blood capillaries, Anat. Rec. 136:254.

    Google Scholar 

  84. Palade, G. E., 1961, Blood capillaries of the heart and other organst, Circulation 24:368–384.

    PubMed  CAS  Google Scholar 

  85. Palade, G. E., Simionescu, M., and Simionescu, N., 1979, Structural aspects of the permeability of the microvascular endothelium, Acta Physiol. Scand. Suppl. 463:11–32.

    CAS  Google Scholar 

  86. Pappenheimer, J. R., 1953, Passage of molecules through capillary wallst,Physiol. Rev. 33:387–423.

    PubMed  CAS  Google Scholar 

  87. Pesonen, M., Ansorge, W., and Simons, K., 1984, Transcytosis of the G protein of vesicular stomatitis virus after implantation into the apical membrane of Madin-Darby canine kidney cells. I. Involvement of endosomes and lysosomes, J. Cell Biol. 99:796–802.

    Article  PubMed  CAS  Google Scholar 

  88. Peters, T. Jr., 1975, Serum albumin, Adv. Prot. Chem. 37:161–245.

    Article  Google Scholar 

  89. Pietra, G. G., Sampson, P., Lanken, P. N., Hansen-Flaschen, J., and Fishman, A. P., 1984, Transcapillary movement of cationized ferritin in the isolated perfused rat lung, Lab. Invest. 49:54–61.

    Google Scholar 

  90. Pino, R. M., 1985, Restriction to endogenous plasma proteins by a fenestrated capillary endothelium: An ultrastructural immunocytochemical study of the choriocapillary endothelium, Am. J. Anat. 172:279–289.

    Article  PubMed  CAS  Google Scholar 

  91. Pino, R. M., and Thouron, C. L., 1983, Vascular permeability in the rat eye to endogenous albumin and immunoglobulin (IgG) examined by immunohistochemical methods, J. Histochem. Cychem. 31:411–416.

    CAS  Google Scholar 

  92. Predescu, D., Simionescu, M., Simionescu, N., and Palade, G. E., 1987, The bifunctional nature of glycated-albumin may account for its enhanced binding and transport by capillary endothelium, in situ, J. Cell Biol. 105:362a.

    Google Scholar 

  93. Raviola, G., and Butler, J. M., 1983, Unidirectional vesicular transport mechanism in retinal vessels, Invest. Ophthalmol. Vis. Sci.24:465–1474.

    Google Scholar 

  94. Renkin, E. M., 1985, Capillary transport of macromolecules: Pores and other endothelial pathways, J. Appl. Physiol. 58:315–325.

    PubMed  CAS  Google Scholar 

  95. Rennke, H. G., Patel, Y., and Venkatachalam, M. A., 1978, Glomerular filtration of proteins: Clearance of anionic neutral and cationic horseradish peroxidase in the rat, Kidney Int. 13:324–328.

    Article  Google Scholar 

  96. Rodewald, R., and Kraehenbuhl, J. P., 1984, Receptor-mediated transport of IgG, J. Cell Bio. 99:159s—164s.

    Article  Google Scholar 

  97. Ryan, U. S., 1986, The endothelial surface and response to injury, Fed. Proc. 45:101–108.

    PubMed  CAS  Google Scholar 

  98. Schneeberger, E. E., 1983, Proteins and vesicular transport in capillary endothelium, Fed. Proc. 42:2419–2424.

    PubMed  CAS  Google Scholar 

  99. Schneeberger, E. E., and Hamelin, M., 1984, Interaction of serum proteins with lung endothelial glycocalyx: Its effect on endothelial permeability, Am. J. Physiol. 246:H206–H217.

    Google Scholar 

  100. Shasby, D. M., and Shasby, S. S., 1985, Active transendothelial transport of albumin: Interstitium to lumen, Circ. Res. 57:903–908.

    PubMed  CAS  Google Scholar 

  101. Simionescu, D., and Simionescu, M., 1983,Differentiated distribution of the cell surface charge on the alveolar-capillary unit: Characteristic paucity of anionic sites on the air-blood barrier, Microvasc. Res. 25:85–100.

    Article  PubMed  CAS  Google Scholar 

  102. Simionescu, M., 1985, Regional differentiation of the surface distribution in the continuous endothelium of the microvasculature, in: Glomerular Dysfunction andBiopathology of the Vascular Wall (A.L. Copley, Y. Hamashima, S. Seno, and M.A. Venkatachalam, eds.), Academic Press Japan, Inc., Tokyo, pp. 3-11.

    Google Scholar 

  103. Simionescu, M., Ghitescu, L., Fixman, A., and Simionescu, N., 1986, Receptor-mediated transcytosis of albumin in vascular endothelium, Acta Biol. Acad. Hung. Sci. 37:104.

    Google Scholar 

  104. Simionescu, M., Ghitescu, L., Fixman, A., and Simionescu, N., 1987, How plasma macromolecules are transported by vascular endothelium, News Physiol. Sci. 2:97–100.

    Google Scholar 

  105. Simionescu, M., and Simionescu, N., 1984, Ultrastructure of the microvascular wall: Functional correlations, in: Handbook of Physiology, Sect. 2, Vol. IV (E.M. Renkin and C.C. Michel, eds.), American Physiological Society, Bethesda, pp 41–101.

    Google Scholar 

  106. . Simionescu, M., and Simionescu, N., 1986, Receptor-mediated transcytosis of plasma molecules by vascular endothelium, in: Fourth International Symposium on the Biology of Vascular Endothelial Cell, Noordwijkerhout, Abstract Volume, p. 21.

    Google Scholar 

  107. Simionescu, M., and Simionescu, N., 1986, Functions of the endothelial cell surface, Annu. Rev. Physiol. 48:279–293.

    Article  PubMed  CAS  Google Scholar 

  108. Simionescu, M., Simionescu, N., and Palade, G. E., 1982, Biochemically differentiated microdomains of the cell surface of capillary endothelium, Ann. N.Y. Acad. Sci. 401:9–24.

    Article  PubMed  Google Scholar 

  109. Simionescu, M., Simionescu, N., and Palade, G. E., 1982, Differentiated microdomains on the luminal surface of capillary endothelium: Distribution of lectin receptors, J. Cell Biol. 94:406–413.

    Article  PubMed  CAS  Google Scholar 

  110. Simionescu, M., Simionescu, N., and Palade, G. E., 1982, Preferential distribution of anionic sites on the basement membrane and the abluminal aspect of the endothelium in fenestrated capillaries, J. Cell Biol. 95:425–434.

    Article  PubMed  CAS  Google Scholar 

  111. Simionescu, M., Simionescu, N., Santoro, F., and Palade, G. E., 1985, Differentiated microdomains of the luminal plasmalemma of murine muscle capillaries: Segmental variations in young and old animals, J. Cell Biol. 100:1396–1407.

    Article  PubMed  CAS  Google Scholar 

  112. Simionescu, M., Simionescu, N., Silbert, J., and Palade, G. E., 1981, Differentiated microdomains on the luminal surface of capillary endothelium. II. Partial characterization of the anionic sites, Cell Biol. 90:614–621.

    Article  CAS  Google Scholar 

  113. Simionescu, N., 1979, The microvascular endothelium: Segmental differentiations; transcytosis, selective distribution of anionic sites, in: Advances in Inflammation Research, Vol. 1 (G. Weissmann, B. Samuelson, and R. Paoletti, eds Raven Press, New York, pp 61–70.

    Google Scholar 

  114. Simionescu, N., 1980, Transcytosis and endocytosis in the endothelial cell, Eur. J. Cell Biol. 22:180.

    Google Scholar 

  115. Simionescu, N., 1981, Transcytosis and traffic of membranes in the endothelial cell, in: International Cell Biology 1980-1981 (H. Schweiger, ed.), Springer-Verlag, Berlin, pp 657–672.

    Chapter  Google Scholar 

  116. Simionescu, N., 1983, Cellular aspects of transcapillary exchange, Physiol. Rev. 63:1536–1579.

    PubMed  CAS  Google Scholar 

  117. Simionescu, N., and Simionescu, M., 1981, Hydrophilic pathways of capillary endothelium, a dynamic system, in: Water Transport across Epithelia (H.H. Ussing, N.B. Bindslev, and O. Sten-Knudsen, eds.), Munksgaard, Copenhagen, pp 228–247.

    Google Scholar 

  118. Simionescu, N., and Simionescu, M., 1984, Fluid-phase and adsorptive transcytosis in the endothelial cell, in: International Symposium on Membrane Biogenesis and Recycling , Kanvami, Abstracts Volume, pp VI–I.

    Google Scholar 

  119. Simionescu, N., and Simionescu, M., 1985, Interactions of endogenous lipoproteins with capillary endothelium in spontaneously hyperlipoproteinemic rats, Microvasc. Res. 30:314–332.

    Article  PubMed  Google Scholar 

  120. Simionescu, N., Simionescu, M., and Palade, G. E.,1972, Permeability of intestinal capillaries: Pathway followed by dextrans and glycogens, J. Cell Biol. 53:365–392.

    Article  PubMed  CAS  Google Scholar 

  121. Simionescu, N., Simionescu, M., and Palade, G. E., 1976, Structural-functional correlates in the transendothelial exchange of water-soluble macromolecules, Thromb. Res. 8(Suppl. 2):257–289.

    Article  PubMed  CAS  Google Scholar 

  122. Simionescu, N., Simionescu, M., and Palade, G. E.,1978, Open junctions in the endotheliumof the postcapillary venules of the diaphragm, J. Cell Biol. 79:27–44.

    Article  PubMed  CAS  Google Scholar 

  123. Simionescu, N., Simionescu, M., and Palade, G. E., 1981, Differentiated microdomains on the luminal surface of capillary endothelium. I. Preferential distribution of anionic sites, J. Cell Biol. 90:605–613.

    Article  PubMed  Google Scholar 

  124. Soda, R., and Tavassoli, M.,1984, Transendothelial transport (transcytosis) of iron-transferrin complex in the bone marrow, J. Ultrastruct. Res. 88:18–29.

    Article  PubMed  CAS  Google Scholar 

  125. Soda, R., and Tavassoli, M., 1984, Liver endothelium and not hepatocytes or Kupffer cells have transferrin receptors, Blood 63:270–276.

    PubMed  CAS  Google Scholar 

  126. Soda, R., Tavassoli, M., and Jacobsen, D. W.,1985, Receptor distribution and the endothelial uptake of transcobalamin II in liver cell suspensions, Blood 65:795–802.

    PubMed  CAS  Google Scholar 

  127. Solenski, N. J., and Williams, S. K.,1985, Insulin binding and vesicular ingestion in capillary endothelium, J. Cell. Physiol. 124:87–95.

    Article  PubMed  Google Scholar 

  128. Spector, A., 1986, Plasma albumin as a lipoprotein, in: Biochemistry and Biology of Plasma Lipoproteins (A.M. Scann and A.A. Spector, eds.), Dekker, New York, pp 247–279.

    Google Scholar 

  129. Stremmel, W., Potter, B. J., and Berk, P. D., 1983, Studies of albumin binding to rat liver plasma membranes, Biochim. Biophys. Acta 756:20–27.

    Article  PubMed  CAS  Google Scholar 

  130. Stremmel, W., Strohmeyer, G., and Berk, P. D., 1986, Hepatocellular uptake of oleate is energy dependent, sodium linked and inhibited by an antibody to a hepatocyte plasma membrane fatty acid binding protein, Proc. Natl. Acad. Sci. USA 83:3584–3588.

    Article  PubMed  CAS  Google Scholar 

  131. Svensjo, E., and Grega, G. J., 1986, Evidence for endothelial cell-mediated regulation of macromolecular permeability by postcapillary venules, Fed. Proc. 45:89–95.

    CAS  Google Scholar 

  132. Tavassoli, M., Kishimoto, T., Soda, R., Kataoka, M., and Haijes, K., 1986, Liver endothelium mediates the uptake of iron-transferrin complex by hepatocytes, Exp. Cell Res. 165:369–379.

    Article  PubMed  CAS  Google Scholar 

  133. Tavassoli, M., Kishimoto, T., and Kataoka, M., 1986, Liver endothelium mediates the hepatocyte’s uptake of ceruloplasmin, J. Cell Biol. 102:1298–1303.

    Article  PubMed  Google Scholar 

  134. Taylor, A. E., and Granger, D. N., 1984, Exchange of macromolecules across the microcirculation, in: Handbook of Physiology, Sect. 2, Vol. IV (E.M. Renkin and C.C. Michel, eds.), American Physiological Society, Bethesda, pp 467–520.

    Google Scholar 

  135. Trevisan, A., Gudat, F., Luoud, M., Guggenheim, R., Krey, G., Durmuller, G., Duggelin, M., Landmann, J., Tondelli, P., and Bianchi, L., 1982, Demonstration of albumin receptors on isolated human hepatocytes by light and scanning electron microscopy, Hepatology 2:823–835.

    Article  Google Scholar 

  136. Trout, J. J., Koenig, H., Lu, C. Y., and Goldstone, A. D., 1986, Acute stimulation of transcytosis in rat heart capillaries following a calcium depletion-repletion cycle is Ca2+ and polyamine dependent, J. Cell Biol. 103:60a.

    Google Scholar 

  137. Turner, M. R., Clough, G., and Michel, C. C., 1983, The effects of cationized ferritin upon the filtration coefficient of single frog capillaries: Evidence that proteins in the endothelial cell coat influence permeability, Microvasc. Res. 25:205–222.

    Article  PubMed  CAS  Google Scholar 

  138. Vasile, E., Nistor, A., Nedelcu, S., Simionescu, M., and Simionescu, N., 1980, Dual pathway of low density lipoprotein transport through aortic endothelium and vasa vasorum, in situ, Eur. J. Cell Biol. 22:181.

    Google Scholar 

  139. Vasile, E., Popescu, G., Simionescu, M., and Simionescu, N., 1986, Enhanced transcytosis and accumulation of (3-very low density lipoproteins in the aorta of rabbits with experimental hyperlipidemia, in: XVIth International Congress of the International Academy of Pathology, Vienna, Abstracts Volume, p. 68.

    Google Scholar 

  140. Vasile, E., Simionescu, M., and Simionescu, N., 1983, Visualization of the binding, endocytosis and transcytosis of low-density lipoprotein in the arterial endothelium in situ,J. Cell Biol. 96:1677–1689.

    Article  PubMed  CAS  Google Scholar 

  141. Vasile, E., and Simionescu, N., 1985,Transcytosis of low density lipoprotein through vascular endothelium, in: Glomerular Dysfunction and Biopathology of Vascular Wall (A.L. Copley, Y. Hamashima, S. Seno, M.A. Venkatachalam, eds.), Academic Press Japan, Inc., Tokyo, pp 87–101.

    Google Scholar 

  142. Villaschi, S., Johns, L., Cirigliano, M., and Pietra, G. G., 1986, Binding and uptake of native and glycosylated albumin-gold complexes in perfused rat lungs,Microvasc. Res. 32:190–199.

    Article  PubMed  CAS  Google Scholar 

  143. Vorbrodt, A. W., and Lossinsky, A. S., 1986 Transport of homologous albumin through various capillary endothelia in mice, J. Cell Biol. 103:193a.

    Google Scholar 

  144. Wagner, R. C., and Andrews, S. B., 1985, Ultrastructure of the vesicular system in rapidly frozen capillary endothelium of the rete mirabile, J. Ultrastruct. Res. 90:172–182

    Article  Google Scholar 

  145. Wagner, R. C., and Casley-Smith, J. R., 1981, Endothelial vesicles—Review, Microvasc. Res. 21:267–298.

    Article  PubMed  CAS  Google Scholar 

  146. Wagner, R. C., and Robinson, C. S., 1984, High-voltage electron microscopy of capillary endothelial vesicles,Microvasc. Res. 28:197–205.

    Article  PubMed  CAS  Google Scholar 

  147. Wagner, R. C., Robinson, C. S., Cross, P. J., and Devenny, J. J., 1983, Endocytosis and exocytosis of transferrin by isolated capillary endothelium, Microvasc. Res. 25:387–396.

    Article  PubMed  CAS  Google Scholar 

  148. Weisiger, R., Gollan, J., and Ockner, R., 1981, Receptor for albumin on the liver cell surface may mediate uptake of fatty acids and other albumin-bound substances, Science 211:1048–1050.

    Article  PubMed  CAS  Google Scholar 

  149. Wfisiger, R. A., Zacks, C. M., Smith, N. D., and Boyer, J. L., 1984, Effect of albumin binding on extraction of sulfobromphtalein by perfused elasmobranch liver: Evidence for dissociationlimited uptake, Hepatology 4:492–501.

    Article  Google Scholar 

  150. Wesselcouch, E. O., Luneau, C. J., Williams, K. J., and Gosselin, R. E., 1984, The failure of serum albumin to affect capillary permeability in the isolated rabbit heart, Microvasc. Res. 28:373–386.

    Article  Google Scholar 

  151. Williams, S. K., 1983, Vesicular transport of proteins by capillary endothelium, Ann. N. Y. Acad. Sci. 416:457–467.

    Article  PubMed  CAS  Google Scholar 

  152. Williams, S. K., Devenny, J. J., and Bittensky, M. W., 1981, Micropinocytotic ingestion of glycosylated albumin by isolated microvessels: Possible role in pathogenesis of diabetic microangiopathy, Proc. Natl. Acad. Sci. USA 78:2393-2397.

    Google Scholar 

  153. Williams, S. K., and Solenski, N. J., 1984, Enhanced vesicular ingestion of nonenzymatically glycosylated proteins by capillary endothelium, Microvasc. Res. 28:311–321.

    Article  PubMed  CAS  Google Scholar 

  154. Witte, S., 1983, The endothelial lining as studied by fluorescent labeling technique in situ, Thromb. Res. 5(Suppl.):93–104.

    Article  PubMed  CAS  Google Scholar 

  155. Wolinsky, H., 1980, A proposal linking clearing of circulating lipoproteins to tissue metabolic activity as a basis for understanding atherogenesis, Circ. Res. 47:301–311.

    PubMed  CAS  Google Scholar 

  156. Yokota, S., 1983, Immunocytochemical evidence for transendothelial transport of albumin and fibrinogen in rat heart and diaphragm,Biomed. Res. 4:577–586.

    CAS  Google Scholar 

  157. . Ghinea, N., Fixman, A., Alexandru, D., Popov, D., Hasu, M., Ghitescu, L., Eskenasy, M., Simionescu, M., and Simionescu, N., 1988, Identification of albumin binding proteins in capillary endothelial cells. J. Cell Biol, (in press).

    Google Scholar 

  158. Simionescu, M., Ghinea, N., Fixman, A., Lasser, M., Kukes, L., Simionescu, N., and Palade, G. E., 1988, The cerebral microvasculature of the rat: Structure and luminal surface properties during early development. J. Submicrosc. Cytol. (in press)

    Google Scholar 

  159. Simionescu, N., and Simionescu, M., 1987. Receptor mediated transcytosis of albumin: Identification of albumin binding proteins in the plasma membrane of capillary endothelium, in: Proceedings of the IV th World Congress on Microcirculation Tokyo, Japan (M. Tsuchiya, M. Asano, Y. Mishima, M. Oda, eds.), Elsevier, Amsterdam and New York, pp 67–82.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Cellular Biology and Pathology, 79691, Bucharest, Romania

    Maya Simionescu

Authors
  1. Maya Simionescu
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institute of Cellular Biology and Pathology, Bucharest, Romania

    Nicolae Simionescu  & Maya Simionescu  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Plenum Press, New York

About this chapter

Cite this chapter

Simionescu, M. (1988). Receptor-Mediated Transcytosis of Plasma Molecules by Vascular Endothelium. In: Simionescu, N., Simionescu, M. (eds) Endothelial Cell Biology in Health and Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0937-6_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-0937-6_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8254-9

  • Online ISBN: 978-1-4613-0937-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation