Abstract
The fluid mosaic model for membrane architecture proposed by Singer and Nicolson states that the integral proteins of membranes are globular amphypathic molecules that are either partially or totally inserted in the lipid bilayer (Singer, 1972). This model continues to have considerable explanatory and predictive value in the analysis of membrane structure and function. The fluid mosaic model depicts the membrane as a two-dimensional solution in which the lipid bilayer acts as a fluid solvent for the globular integral proteins. As a consequence of their mobility in the lipid bilayer, the membrane proteins are able to perform the varied processes of catalysis and transport carried out by biological membranes.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Albers, R. W., 1976, in: The Enzymes of BiologicaÌ Membranes, (A. Mattinosi, ed.), Vol. Ill, pp. 283–301, Plenum Press, New York.
Alvarado, R. H., and Moody, A., 1970, Am. J Physiol 218:1510–1516.
Baker, P. F., 1972, in: Metabolic Pathways (L. E. Hokin, ed.). Vol. VI, pp. 243–268, Academic Press, New York.
Bonting, S. L., and Caravaggio, L. L., 1963, Arck Biochem. Biophys. 101:37–46.
Chen, P. S., Toribara, T. Y., and Warner, H. 1956, Anal. Chem. 28:1756–1758.
Dahl, J., and Hokin, L. E., 1974, Ann. Rev. Biochem. 43:327–356.
De Pont, J. J. H. M., Van Prooijen-Van Eeden, A., and Bonting, S. L., 1978, Biochim. Biophys. Acta 508:464–477.
Drapeau, P., and Blastein, R., 1980, J. Biol Chem. 255:7827–7834.
Edelman, I. S., 1974, in: Drug and Transport Processes (B. A. Callingham, ed.), pp. 101–110, MacMillan, London.
Fleischer, B., and Zambrano, F., 1974, J. Biol Chem. 249:5995–6003.
Fleischer, B., Zambrano, F., and Fleischer, S., 1974, J. Supramolecular Structure 2:737–750.
Glynn, Z. M., and Karlish, S. J. D., 1975, Ann. Rev. Phys. 37:13–55.
González, E., and Zambrano, F., 1983, Biochim. Biophys. Acta 728:66–72.
González, M., Morales, M., and Zambrano, F., 1979, J. Membrane Biol 51:347–359.
Hansson, C. G., Karlsson, K.-A., and Samuelsson, B. E., 1978, J. Biochem. 83:813–819.
Harris, W. E., 1985, Biochemistry 24:2873–2883.
Jedlicki, A., and Zambrano, f., 1985, Arch. Biochem. Biophys. 238:558–564.
JØrgensen, P. L., 1974, Biochim, Biophys. Acta 356:53–67.
JØrgettsen, P. L., 1980, Physiol. Rev. 60:864–908.
Karlsson, K.-A., 1976, in: Structure of Biological Membrane (A. Abrahamson and E. Pascher, eds.), pp. 245–274, University of Göteborg.
Karlsson, K.-A., Samuelsson, B. E., and Steen, G. O., 1971, J. Membrane Biol. 5:169–184.
Kean, E. L., 1968, J. Lipid. Res. 9:319–327.
Kyte, J., 1975, J. Biol. Chem. 250:7443–7449.
Lazdunski, M., 1972, in: Current Topics in Cellular Regulation (B. L. Horecker and E. R. Stadtman, eds.), Vol. VI, pp. 267–310, Academic Press, New York.
Mehl, E., and Jatzkawitz, H., 1968, Biochim. Biophys. Acta 151:619–627.
Nicolson, G. L., 1976, Biochim. Biophys. Acta 457:57–64.
Nicolson, G. L., and Singer, S. L., 1974, J. Cell Biol 60:236–241.
Perrone, J. R., Hackeney, J. F., Dixon, J. F., and Hokin, L. E., 1975, J. Biol Chem. 250:4178–4184.
Post, R. L., Sen, A. K., and Rosenthal, A. S., 1965, J. Biol, Chem. 240:1437–1445.
Roloefson, B., and Deenen, L. L. M., 1973, Eur. J. Biochem. 40:245–257.
Schuurmans Stekhoven, F., and Bonting, S. L., 1981, Ann. Rev. Physiol 61:1–76.
Sen, R C., and Ray, T. F., 1979, Arch. Biochem. Biophys. 198:548–555.
Singer, S. J., 1976, in: Structure of Biological Membrane (A. Abrahamson and F. Pascher, eds.), pp. 443–461, University of Goteborg, 1976.
Singer, S. J., and Nicolson, G. L., 1972, Science 175:720–731.
Skou, J. C., 1957, Biochim. Biophys. Acta 23:394–401.
Skou, J. C., 1975, Quart. Rev. Biophys. 7:401–434.
Stein, W. D., Web, W. R., Karlish, S. J. D., and Eilam, Y., 1973, Proc. Natl Acad. Sci. USA. 70:275–278.
Tsai, K. H., and Lenard, J., 1975, Nature (London) 253:554–557.
Verklaij, A. J., Zwaal, R. F. A., Roelofsen, B., Comfurius, P., Kastelijn, D., and Van Deenen, L. m., 1973, Biochim. Biophys. Acta 323:178–182.
Walker, J. A., and Wheeler, K. P., 1975, Biochim. Biophys. Acta 394:135–144.
Zambrano, F., and Rojas, M., 1986, Arch. Biochem. Biophys. 253:87–93.
Zambrano, F., Fleischer, S., and Fleischer, B., 1975, Biochim. Biophys. Acta 380:357–369.
Zambrano, F., Morales, M., Fuentes, N., and Rojas, M.S 1981, J. Membrane Biol 63:71–75
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Plenum Press, New York
About this chapter
Cite this chapter
Zambrano, F., Rojas, M. (1988). Lipid—Protein Interactions in the Function of the Na+ and H+ Pumps Role of Sulfatide. In: Hidalgo, C. (eds) Physical Properties of Biological Membranes and Their Functional Implications. Series of the Centro de Estudios Científicos de Santiago. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0935-2_8
Download citation
DOI: https://doi.org/10.1007/978-1-4613-0935-2_8
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8253-2
Online ISBN: 978-1-4613-0935-2
eBook Packages: Springer Book Archive