Abstract
We have demonstrated that serotonin antagonists preserve neurological function in two different animal models. In one model, reversible occlusion was studied; in the other, irreversible ischemia was produced. In both instances, the protective effects were unequivocal. Alterations of the tissue concentrations of serotonin and its primary metabolite were not demonstrated during the stages of ischemia when irreversible damage was occurring. Thus, a new approach to the understanding of the mechanisms of action of serotonin is required. Although the mechanisms of injury reduction are not yet known, these findings make a compelling case for the utility of serotonin antagonists in the emergency therapy of such problems as cardiac arrest to prevent cerebral damage while the cardiac status is stabilized, and possibly for stroke-in-evolution to prevent continued progressive extension of damage. It may also be possible to give such therapy prophylactically in high-risk situations such as increasingly frequent transient ischemic attacks or before high-risk surgical procedures.
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© 1988 Plenum Press
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Zivin, J.A. (1988). Serotonin Antagonists Reduce Central Nervous System Ischemic Damage. In: Stein, D.G., Sabel, B.A. (eds) Pharmacological Approaches to the Treatment of Brain and Spinal Cord Injury. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0927-7_4
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DOI: https://doi.org/10.1007/978-1-4613-0927-7_4
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