The pharmacological approach to first-stage recovery in acute stroke is aimed at controlling edema and improving microcirculation and cellular protection in the ischemic penumbra. Limiting lesion size with these early measures may influence outcome significantly. Careful methodology is necessary to measure recovery rates and outcome. The extent of recovery is influenced by initial severity. Lesion size in a stroke population correlates significantly with outcome measures. Recovery in the initial period, the first 3 months, is significantly greater in all groups and in all functional deficits. Evidence appears to indicate that both homologous contralateral and ipsilateral functionally connected hemispheric structures play a role in recovery. Comprehension and semantic processing may have more widespread cerebral compensation than motor and assembly functions of language, which are more left hemisphere dependent. Pharmacological studies in recovery must consider these factors and utilize more precise methodology to define functional deficits.


Cerebral Blood Flow Acute Stroke Ischemic Penumbra Calcium Entry Blocker Initial Severity 
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Copyright information

© Plenum Press 1988

Authors and Affiliations

  • Andrew Kertesz
    • 1
  1. 1.Research Institute, St. Joseph’ HospitalUniversity of Western OntarioLondonCanada

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