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Neurotransmitters and Cortical Function pp 415–435Cite as

Adenosine: A Molecule for Synaptic Homeostasis?

Evolution of Current Concepts on the Physiological and Pathophysiological Roles of Adenosine in the Brain

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Abstract

Among the neurotransmitters and other neuroactive substances discussed in the previous chapters, adenosine is the endogenous molecule with the most commonly appreciated effects on the mind, as each cup of coffee may remind us. However, in contrast to the relatively well-established ideas about the transmitter amino acids, acetylcholine, and catecholamines, research on adenosine is currently faced with an increasing amount of data in need of an integrated functional scheme. Reflections on the way our ideas have evolved regarding several possible schemes will emphasize the mutual dependence between our understanding of synaptic transmission and the specific roles we often assign to endogenous neuroactive molecules.

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  1. Department of Physiology, University of Patras Medical School, Patras 261 10, Greece

    George K. Kostopoulos

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  1. McGill University and Montreal Neurological Institute, Montreal, Quebec, Canada

    Massimo Avoli  & Pierre Gloor  & 

  2. University of Montreal, Montreal, Quebec, Canada

    Tomás A. Reader

  3. McGill University and Royal Victoria Hospital, Montreal, Quebec, Canada

    Robert W. Dykes

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Kostopoulos, G.K. (1988). Adenosine: A Molecule for Synaptic Homeostasis?. In: Avoli, M., Reader, T.A., Dykes, R.W., Gloor, P. (eds) Neurotransmitters and Cortical Function. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0925-3_27

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  • DOI: https://doi.org/10.1007/978-1-4613-0925-3_27

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