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Cortical Monoamines and Injured Brain

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Abstract

It is well established that brain injury which causes gross damage to vascular elements results in opening of the blood-brain barrier and an extravasation of fluid, giving rise to vasogenic edema (Katzman and Pappius, 1973). The edema has been generally accepted as the underlying cause of functional disturbances in conditions in which it occurs, although this assumption has not been validated and has been questioned (Pappius and McCann, 1969; Sutton et al., 1980; Pappius and Wolfe, 1984). On the other hand, brain injury is associated with many other events all of which can be envisaged as leading to disturbances of neuronal function independently of the develop-ment of cerebral edema (Pappius and Wolfe, 1984). These include release of arachidonic acid from membrane phospholipids and formation of prostaglandins and thromboxanes (Wolfe, 1982), release of neurotransmitters (Fenske et al., 1976; Bareggi et al., 1975; Vecht et al., 1975) and possibly the generation of free radicals (Demopoulos et al., 1972). In the context of this sym-posium, effects of injury on neurotransmitter systems are of particular interest.

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Authors and Affiliations

  1. The Goad Unit of The Dormer Laboratory of Experimental Neurochemistry, Montreal Neurological Institute, McGill University, Montreal, Quebec, H3A 2B4, Canada

    Hanna M. Pappius

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  1. Hanna M. Pappius
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Editors and Affiliations

  1. McGill University and Montreal Neurological Institute, Montreal, Quebec, Canada

    Massimo Avoli  & Pierre Gloor  & 

  2. University of Montreal, Montreal, Quebec, Canada

    Tomás A. Reader

  3. McGill University and Royal Victoria Hospital, Montreal, Quebec, Canada

    Robert W. Dykes

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© 1988 Plenum Press, New York

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Pappius, H.M. (1988). Cortical Monoamines and Injured Brain. In: Avoli, M., Reader, T.A., Dykes, R.W., Gloor, P. (eds) Neurotransmitters and Cortical Function. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0925-3_25

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  • DOI: https://doi.org/10.1007/978-1-4613-0925-3_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8248-8

  • Online ISBN: 978-1-4613-0925-3

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