Abstract
Many of the biological effects of neuronal activity are mediated by the sequential activation of first, second, third (etc.) messengers (for review, see Nestler and Greengard, 1984). First mes-sengers, such as neurotransmitters and neurohormones, work through second messengers such as cAMP, cGMP, and calcium to activate protein kinases that in turn phosphorylate third messenger phosphoproteins. The final messengers in this cascade are the effector molecules that directly alter cell metabolism and/or physiology. DARPP-32 (dopamine- and cAMP-regulated phosphoprotein of molecular weight 32,000) is a third messenger phosphoprotein in this cascade. It is regulated by the first messenger dopamine (DA) and by the second messenger cAMP. The possibility exists that other first messengers that increase intracellular cAMP in DARPP-32-containing neurons may also regulate DARPP-32 phosphorylation. In this paper, neurons in the cerebral cortex that contain DARPP-32 are examined.
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© 1988 Plenum Press, New York
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Ouimet, C.C. (1988). Cerebrocortical Neurons Containing DARPP-32, a Dopamine- and Adenosine 3′:5′-Monophosphate-Regulated Phosphoprotein. In: Avoli, M., Reader, T.A., Dykes, R.W., Gloor, P. (eds) Neurotransmitters and Cortical Function. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0925-3_23
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DOI: https://doi.org/10.1007/978-1-4613-0925-3_23
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