Modulation of Neuronal Excitability by Acetylcholine

  • E. Wanke
  • A. Ferroni


Several substances have been shown to act as neurotransmitters at a synaptic level. These include acetylcholine (ACh), noradrenaline (NA), adrenaline, and γ-aminobutyric acid (GABA) as well as a variety of other amino acids, amines, and peptides [such as serotonin (5-HT), glycine, glutamic acid, dopamine, and luteinizing hormone-releasing factor (LHRH)]. For a review see Krnjević (1974). These transmitters interact with specific chemoreceptor molecules, changing the permeability of the membrane to specific ions, and producing either an excitatory or an inhibitory synaptic potential. Each transmitter substance may control different specific permeability channels.


Dorsal Root Ganglion Muscarinic Receptor Outward Current Sympathetic Ganglion Sympathetic Ganglion Cell 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • E. Wanke
    • 1
  • A. Ferroni
    • 1
  1. 1.1Department of General Physiology and BiochemistryUniversity of MilanMilanItaly

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