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The Synthesis and Storage of Acetylcholine in Mammalian Cholinergic Nerve Terminals

  • Chapter
Neurotransmitters and Cortical Function

Abstract

The notion that acetylcholine (ACh) might function as a neurotransmitter in the mammalian CNS was mentioned by Dale in his 1937 William Henry Welch Lectures (Dale, 1938). Almost 50 years later, we have some understanding of this function and of the consequences of dysfunction. The function of ACh in the CNS appears to relate to enhancement of neuronal excitability, and it is significant that the first direct demonstration that increased ACh release in cerebral cortex is associated with increased neuronal activity in unanesthetized animals was made in H. H. Jasper’s laboratory (Celesia and Jasper, 1966). The dysfunctions of central cholinergic neurons appear to relate to conditions associated with memory loss, and it is equally significant that Dr. Jasper makes no contribution to the statistics associating these parameters: it is evident that his central cholinergic neurons are fully functional.

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  1. Department of Pharmacology, McGill University, Montreal, Quebec, H3G 1Y6, Canada

    B. Collier

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  1. McGill University and Montreal Neurological Institute, Montreal, Quebec, Canada

    Massimo Avoli  & Pierre Gloor  & 

  2. University of Montreal, Montreal, Quebec, Canada

    Tomás A. Reader

  3. McGill University and Royal Victoria Hospital, Montreal, Quebec, Canada

    Robert W. Dykes

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Collier, B. (1988). The Synthesis and Storage of Acetylcholine in Mammalian Cholinergic Nerve Terminals. In: Avoli, M., Reader, T.A., Dykes, R.W., Gloor, P. (eds) Neurotransmitters and Cortical Function. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0925-3_16

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  • DOI: https://doi.org/10.1007/978-1-4613-0925-3_16

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