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Rate-Limiting Steps in the Synthesis of GABA and Glutamate

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Neurotransmitters and Cortical Function

Abstract

The theme of this symposium, the relationship between the chemical activity of the nervous system and its electrical and behavioral functions, has been Dr. Jasper’s major interest during the past 20 years. I would like to contribute to this topic by presenting our recent data on the contrasting mechanisms involved in the control of the synthesis of the transmitters glutamate and GABA. This information can be useful in explaining processes involved in pathological changes in excitability and can suggest measures that are likely to rectify abnormalities in the release of amino acid transmitters. First, however, the rather extensive literature on the metabolic compartments of amino acid synthesis will be briefly reviewed, because the new observations reported here are based on concepts that have evolved during the past 25 years.

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Authors and Affiliations

  1. Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, B3H 4H7, Canada

    John C. Szerb

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  1. John C. Szerb
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Editors and Affiliations

  1. McGill University and Montreal Neurological Institute, Montreal, Quebec, Canada

    Massimo Avoli  & Pierre Gloor  & 

  2. University of Montreal, Montreal, Quebec, Canada

    Tomás A. Reader

  3. McGill University and Royal Victoria Hospital, Montreal, Quebec, Canada

    Robert W. Dykes

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© 1988 Plenum Press, New York

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Szerb, J.C. (1988). Rate-Limiting Steps in the Synthesis of GABA and Glutamate. In: Avoli, M., Reader, T.A., Dykes, R.W., Gloor, P. (eds) Neurotransmitters and Cortical Function. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0925-3_10

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  • DOI: https://doi.org/10.1007/978-1-4613-0925-3_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8248-8

  • Online ISBN: 978-1-4613-0925-3

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