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Role of Free Radical Lipid Peroxidation in Burn and Endotoxin Shock

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Lipid Mediators in the Immunology of Shock

Part of the book series: NATO ASI Series ((NSSA,volume 139))

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Abstract

Enhanced free radical generation leading to lipid peroxidation has been claimed to be associated with various disorders (Bulkey, 1983). There is considerable indirect evidence supporting a role for oxygen radicals in circulatory shock. Crowell et al. (1969) and Cunningham and Keaveny (1978) reported that allopurinol, a competitive inhibitor of xanthine oxidase, substantially increased the survival rate of dogs subjected to hemorrhagic shock. Severe burns result in both local and systemic hemodynamic changes (Gilmore and Handford, 1956; Wolfe and Miller, 1976; Adams et al., 1981), as well as in endocrine (Turinsky et al., 1977), neuroendocrine (Cova and Glaviano, 1968; Goodall and Moncrief, 1965), and metabolic (Robinson and Miller, 1981; Wolfe et al., 1977) alterations. Acute endotoxin shock is rapidly produced with Escherichia coli endotoxin (Balis et al., 1978).

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Author information

Authors and Affiliations

  1. First Department of Medicine, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, 602, Japan

    T. Yoshikawa, N. Yoshida, H. Miyagawa, T. Takemura, T. Tanigawa, M. Murakami & M. Kondo

Authors
  1. T. Yoshikawa
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  2. N. Yoshida
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  3. H. Miyagawa
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  4. T. Takemura
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  5. T. Tanigawa
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  6. M. Murakami
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  7. M. Kondo
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Editor information

Editors and Affiliations

  1. Centre de Traitement des Brules, Hopital d’Instruction des Armees Percy, Clamart, France

    M. Paubert-Braquet

  2. Institut Henri Beaufour, Le Plessis-Robinson, France

    P. Braquet

  3. Longwood Area Trauma Center, Harvard Medical School, Boston, Massachusetts, USA

    B. Demling

  4. St. Thomas Hospital, Nashville, Tennessee, USA

    J. R. Fletcher

  5. Georgetown University Medical Center, Washington, D.C., USA

    M. Foegh

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© 1987 Plenum Press, New York

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Yoshikawa, T. et al. (1987). Role of Free Radical Lipid Peroxidation in Burn and Endotoxin Shock. In: Paubert-Braquet, M., Braquet, P., Demling, B., Fletcher, J.R., Foegh, M. (eds) Lipid Mediators in the Immunology of Shock. NATO ASI Series, vol 139. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0919-2_9

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  • DOI: https://doi.org/10.1007/978-1-4613-0919-2_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8245-7

  • Online ISBN: 978-1-4613-0919-2

  • eBook Packages: Springer Book Archive

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