Arterial Wall Reaction Following Electrical Local De-Endothelialization
Endothelial continuity is essential for vascular homeostasis as its maintenance prevents local thromboformation and atherogenesis (1). If it is well known that small, restricted endothelial denudation zones may occur as the result of hemodynamics (2), homocystinemia (3), generation of free oxygen species (4), and angiotensin challenge (5), In these conditions, only a few endothelial cells are affected and no myointimal thickening occurs. More recently, Hansson and Schwartz (6), described focal spontaneous cell death in rat aortic endothelium following a long phase of gradual detachment of the affected endothelial cells, but without significant exposure of the subendothelial structures because migration of the normal surrounding cells rapidly covered the area of denudation.
KeywordsEndothelial Cell Loss Denude Area Electrical Current Application Normal Surrounding Cell Intimal Structure
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