Skip to main content
SpringerLink
Log in

Elective Immunosuppression

  • Conference paper
Lipid Mediators in the Immunology of Shock

Part of the book series: NATO ASI Series ((NSSA,volume 139))

  • 55 Accesses

Abstract

The anergy which is associated with trauma, burn injury and sepsis shares similarities with the pharmacologically induced immunosuppression of organ transplant patients. These patients have the same high risk of infections which also causes mortality as in the trauma and burn patients. The increased risk of infection in transplant patients is mainly due to prednisone, although both azathioprine, an inhibitor of DNA replication, and cyclosporin A, an inhibitor of interleukin 2 (IL-2) formation, may play some role in the increased incidence of infection. The immunodeficiency characteristic of burn patient has been suggested to be mediated by a deficiency in IL-2 production. This may however only be a partial explanation since patients treated with CsA do not seem to have a substantial increased risk of infections although they are immunosuppressed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Antonacci, A.C., Good, R.A., and Gupta, S.: T-cell subpopulations following thermal injury. Surgery, Gynecology and Obstetrics 155:1 (1982).

    PubMed  CAS  Google Scholar 

  2. Snyder, D.S., and Unanue, E.R.: Corticosteroids inhibit murine macrophage la expression and interleukin 1 production. J. Immunol.129:1803 (1982).

    PubMed  CAS  Google Scholar 

  3. Kronke, M., Leonard, W.J., Depper, J. et al.: Cyclosporin A inhibits T-cell growth factor gene expression at the level mRNA transcription. Proc. Nat. Acad. Sci. 81:5214 (1984).

    Article  PubMed  CAS  Google Scholar 

  4. Braquet, M, Lavaud, P., Dormont, D. et al.: Leukocytic function in burn-injured patients. Prostaglandins 29:747 (1985).

    Article  PubMed  CAS  Google Scholar 

  5. Drath, D.B., and Kahan B.D.: Phagocytic cell function in response to immunosuppressive therapy. Arch. Surg. 119:156 (1984).

    PubMed  CAS  Google Scholar 

  6. Foegh, M.L., Alijani, M.R., Helfrich, G.B., and Ramwell, P.W.: Eicosanoids and organ transplantation. Ann. Clin. Res. 16:318 (1984).

    PubMed  CAS  Google Scholar 

  7. Foegh, M.L., Khirabadi, B.S., Rowles, J.R., Braquet, P., and Ramwell, P.W.: Inhibition of PAF and leukotriene expression in acute cardiac allograft rejection in rats. Pharmacol. Res. Commun.

    Google Scholar 

  8. Foegh, M.L., Khirabadi, B.S., Braquet, P., and Ramwell, P.W.: Prolongation of cardiac allograft survival with BN 52021, a specific antagonist of platelet—activating factor. Transplantation 42:86 (1986).

    PubMed  CAS  Google Scholar 

  9. Foegh ML, Khirabadi BS, and Ramwell PW: Prolongation of experimental cardiac allograft survival with thromboxane related drugs. Transplantation 40:124 (1985).

    Article  PubMed  CAS  Google Scholar 

  10. Foegh, M.L., Cooley, C., Helfrich, G.B. et al.: Urine i-TXB2 in renal allograft rejection. Lancet 2:431 (1981).

    Article  PubMed  CAS  Google Scholar 

  11. Steinhauer, H.B., Wilms, H., Ruther, M., and Schollmeyer, P.: Clinical experience with urine Thromboxane B2 in acute renal allograft rejection. Transpl. Proc. 18 (suppl. 4):98 (1986).

    Google Scholar 

  12. Hirata, F., Schiffman, E., Venkatasubramanian, K., Solomon D., and Axelrod, J.: A phosphplopase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids. Proc. Nat. Acad. Sci. 77:2533 (1980).

    Article  PubMed  CAS  Google Scholar 

  13. Calne, R.Y.: Inhibition of the rejection of renal homografts in dogs by purine analogues. Transplant. Bull. 28:65 (1961).

    PubMed  CAS  Google Scholar 

  14. Neild, G., Rocchi, G., Imberti, L., et al.: Effect of cyclosporine on prostacyclin synthesis by vascular tissue. Thromb. Res. 32:373 (1983).

    Article  PubMed  CAS  Google Scholar 

  15. Fan, T.-P.D., and Lewis, G.P.: Mechanism of cyclosporin A induced inhibition of prostacyclin synthesis by macrophages. Prostaglandins 30:735 (1985).

    Article  PubMed  CAS  Google Scholar 

  16. Farrar, W.L., and Humes, J.L.: The role of arachidonic acid metabolism in the activities of interleukin 1 and 2. J. Immunol. 135:1153 (1985).

    PubMed  CAS  Google Scholar 

  17. Rapaport, R.S., and Dodge, G.R.: Prostaglandin inhibits the production of human interleukin 2. J. Exp. Med. 155:943 (1982).

    Article  Google Scholar 

  18. Dinarello, C.A., Monnoy, S.O., and Rosenwasser, L.J.: Role of arachidonate metabolism in the immunoregulatory function of human leukocytic pyrogen/lymphocyte activating factor/interleukin 1. J. Immunol. 130:890 (1983).

    PubMed  CAS  Google Scholar 

  19. Rola-Pleszczynski, M., and Gagnon, L.: Natural killer cell function modulated by leukotriene B4: mechanism of action. Transplant. Proc. 18 (suppl. 4):44 (1986).

    CAS  Google Scholar 

  20. Goodwin, J.S.: Role of leukotriene B4 in T-cell activation. Transpl. Proc. 18 (suppl. 4):49 (1986).

    CAS  Google Scholar 

  21. Payan, D.G., and Goetzl, E.J.: Specific supppression of human T-lymphocyte function by leukotriene B4. J. Immunnol. 131:551 (1983).

    CAS  Google Scholar 

  22. Goodwinn, J.S., Atluru, D., Sierakowski, S., and Lianos, E. A.: Mechanism of action of glucocorticoids. Inhibition of T-cell proliferation and interleukin 2 production by hydrocortisone is reversed by leukotriene B4. J. Clin. Invest. 77:1244 (1986).

    Article  Google Scholar 

  23. Payan, D.G., and Goetzl, E.J.: The dependence of human T-lymphocyte migration of the 5-lipoxygenation of endogenous arachidonic acid. J. Clin. Immunol. 1:266 (1981).

    Article  CAS  Google Scholar 

  24. Kelly, J.P., Johnson, M.C., Parker, C.W.,: Effect of inhibitors of arachidonic acid metabolism on mitogenesis in human lymphocytes: possible role of thromboxanes and products of the lipoxygeenase pathway. J. Immunol. 122:1572 (1979).

    PubMed  Google Scholar 

  25. Foegh, M.L., Maddox, Y.T., and Ramwell, P.W.: Human peritoneal eosiniphils and formation of arachidonate cyclooxygenase products. Scand. J. Immunol. 23:599 (1986).

    Article  PubMed  CAS  Google Scholar 

  26. Ceuppens, J.L., Vertessen, S., Deckmyn, H., and Vermylen, J.: Effect of thromboxane A2 on lymphocyte proliferation. Cell. Immunol. 90:458 (1985).

    Article  PubMed  CAS  Google Scholar 

  27. Johnson, H.M., and Torres, B.A.: Leukotrienes: positive signals for regulation of gamma-interferon production. J. Immunol. 132:413 (1984).

    PubMed  CAS  Google Scholar 

  28. Snyder, D.S., Beller, D.I., and Unanue, E.R.: Prostaglandins modulate macrophage la expression. Nature 299:163 (1982).

    Article  PubMed  CAS  Google Scholar 

  29. Snyder, D.S., and Unanue, E.R.: Corticosteroids inhibit murine macrophage la expression and interleukin 1 production. J. Immunol. 129:1803 (1982).

    PubMed  CAS  Google Scholar 

  30. Basham, T.Y., and Merigan, T.C.: Recombinant interferon-gamma increases HLA-DR synthesis and expression. J. Immunol. 130:1492 (1983).

    PubMed  CAS  Google Scholar 

  31. Foegh, M.L., Khirabadi, B.S., and Ramwell, P.W.: Improved ratr cardiac allograft survival with non-steroidal pharmacologic agents related to eicosanoids. Transpi. Proc. In press.

    Google Scholar 

  32. Serhan, C.N., Hamberg, M., Ramstedt, U., and Samuelsson, B.: Lipoxins: stereochemistry, biosynthesis and biological activities. Adv. Prostagl. Thrombox. Leukotr. Res. 16:83 (1986).

    CAS  Google Scholar 

  33. Rokash, J., and Fitzsimmons, B.: Lipoxins do they have a biological role? Transpl Proc 18 (suppl. 4):7 (1986).

    Google Scholar 

  34. Foegh, M.L., Hartmann, D.-P., Rowles, J.R. et al.: Leukotrienes, thromboxane and PAF in organ transplantation. Adv. Prostagl. Thrombox. Leukotr. Res. 17:144 (1987).

    Google Scholar 

  35. Foegh, M.L., Braquet, P, Khirabadi, B.S., Rowles, J.R., and Ramwell, P.W.: Inhibition of PAF and leukotriene expression in acute cardiac allograft rejection in rats. Biochem. Res. Comm 18:127 (1986).

    Google Scholar 

  36. Foegh, M.L., Alijani, M.R., Helfrich, G.B., Khirabadi, B.S., Schreiner, G.E., and Ramwell, P.W.: In: Prostaglandins Leukotrienes Lipoxins, Bailey M (ed) New York, Plenum Press, 1985.

    Google Scholar 

  37. Quagliata, F., Lawrence, V.J.W., and Philips-Quagliata, J.M.: Prostaglandin E-, as a regulator of lymphocyte function. Cell. Immunol. 6:457 (1973).

    Article  PubMed  CAS  Google Scholar 

  38. Anderson C.B., Jaffe, B.M., and Graff, R.J.: Prolongation of murine skin allografts by prostaglandin E. Transplantation 23:244 (1977).

    Article  Google Scholar 

  39. Mertin, J., and Hunt, R.: Influence of polyunsaturated fatty acids on survival of skin allografts and tumor incidence in mice. Proc. Natl. Acad. Sci. 73:928 (1976).

    Article  PubMed  CAS  Google Scholar 

  40. Franks, D.J., MacManus, J.P., and Whitfield, J.F.: The effect of prostaglandins on cyclic AMP production and cell proliferation in thymic lymphocytes. Biochem. Biophys. Res. Commun. 44:1177 (1971).

    Article  PubMed  CAS  Google Scholar 

  41. Maddox, Y.T., Foegh, M.L., Zeligs, B., Bellanti, J. Zmudka, M., Ramwell, P.W.: A routine source of human peritoneal macrophages. Scand. J. Immunol. 19:23 (1984).

    Article  PubMed  CAS  Google Scholar 

  42. Van Epps, D.: Suppression of human lymphocyte migration by PGE2 Inflammation 5:81 (1981).

    Article  PubMed  Google Scholar 

  43. Strom, T.B., Carpenter, C.B.: Prostaglandin as an effective antirejection therapy in rat renal allograft recipients. Transplantation 35:279 (1983).

    Article  PubMed  CAS  Google Scholar 

  44. Rowles, J.R., Foegh, M.L., Khirabadi, B.S., and Ramwell, P.W.:The synergistic effect of cyclosporine and iloprost on survival of rat cardiac allografts. Transplantation 42:94 (1986).

    PubMed  CAS  Google Scholar 

  45. Ito, S., Camussi, G., Tetta, C., Milgrom, F., and Andres, G.: Hyperacute renal allograft rejection in the rabbit. Lab. Invest. 51:148 (1984).

    PubMed  CAS  Google Scholar 

  46. Khirabadi, B.S., Foegh, M.L., and Ramwell, P.W.: Urine immunoreactive thromboxane B2 in rat cardiac allograft rejection. Transplantation 39:6 (1985).

    PubMed  CAS  Google Scholar 

  47. Foegh, M.L., Alijani, M.R., Helfrich, G.B., et al.:Thromboxane and leukotrienes in clinical and experimental transplant rejection. Adv. Prostagl. Thrombox. Leukotr. Res. 13:209 (1985).

    CAS  Google Scholar 

  48. Foegh, M.L., Eliasen, K., Johansen, S., Helfrich, B.G., and Ramwell, P.W.: Coronary artery thrombosis and elevated urine immunoreactive thromboxane B2. Prostaglandins 32:781 (1986).

    Article  PubMed  CAS  Google Scholar 

  49. Foegh, M.L., Alijani, M.R., Helfrich, G.B., Khirabadi, B.S., Lim, K., and Ramwell, P.W.: Lipid mediators in organ transplantation. Transplant. Proc. 18 (suppl. 4):20 (1986).

    CAS  Google Scholar 

  50. Kawagushi, A., Goldman, M.H., Shapiro, R., et al.: Increase in urinary thromboxane B2 in rats caused by cyclosporine. Transplantation 40:214 (1985).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, Division of Transplantation, Georgetown University Medical Center, Washington D.C., USA

    M. L. Foegh, M. R. Alijani, G. B. Helfrich & K. Lim

  2. Department of Physiology & Biophysics, Georgetown University Medical Center, Washington D.C., USA

    B. S. Khirabadi & P. W. Ramwell

Authors
  1. M. L. Foegh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. R. Alijani
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. B. Helfrich
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. B. S. Khirabadi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. K. Lim
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. P. W. Ramwell
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Centre de Traitement des Brules, Hopital d’Instruction des Armees Percy, Clamart, France

    M. Paubert-Braquet

  2. Institut Henri Beaufour, Le Plessis-Robinson, France

    P. Braquet

  3. Longwood Area Trauma Center, Harvard Medical School, Boston, Massachusetts, USA

    B. Demling

  4. St. Thomas Hospital, Nashville, Tennessee, USA

    J. R. Fletcher

  5. Georgetown University Medical Center, Washington, D.C., USA

    M. Foegh

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Plenum Press, New York

About this paper

Cite this paper

Foegh, M.L., Alijani, M.R., Helfrich, G.B., Khirabadi, B.S., Lim, K., Ramwell, P.W. (1987). Elective Immunosuppression. In: Paubert-Braquet, M., Braquet, P., Demling, B., Fletcher, J.R., Foegh, M. (eds) Lipid Mediators in the Immunology of Shock. NATO ASI Series, vol 139. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-0919-2_43

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-0919-2_43

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8245-7

  • Online ISBN: 978-1-4613-0919-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation